NME1

Gene Symbol NME1
Entrez Gene 4830
Alt Symbol AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1
Species Human
Gene Type protein-coding
Description NME/NM23 nucleoside diphosphate kinase 1
Other Description NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|non-metastatic cells 1, protein (NM23A) expressed in|nucleoside diphosphate kinase A|tumor metastatic process-associated protein
Swissprots Q86XQ2 Q6FGK3 P15531 Q9UDJ6
Accessions CAA53270 EAW94568 P15531 AF487339 AAO85436 AK291105 BAF83794 AK309160 AL360166 AL360191 BC000293 AAH00293 BC018994 AAH18994 BE727815 BF965472 BG531372 BG715560 BG757842 BI666785 BM479520 BU600979 CR542104 CAG46901 CR542115 CAG46912 D28367 BAA05733 S68891 X17620 CAA35621 X73066 CAA51527 NM_000269 NP_000260 NM_198175 NP_937818
Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Tissue Specificity Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10512675, ECO:0000269|PubMed:12601555, ECO:0000269|PubMed:16442775}.
Top Pathways Purine metabolism, Pyrimidine metabolism

Rat NME1 / NM23 ELISA Kit (Sandwich ELISA) - LS-F8636 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.115 ng/ml
Range 0.313-20 ng/ml

Human NME1 / NM23 ELISA Kit (Sandwich ELISA) - LS-F12128 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.313-20 ng/ml

Neuroblastoma, Suppression Of Tumorigenicity 1 (NBL1), Human, ELISA Kit - SEP853Hu from ARP American Research Products

Category ELISA Kit
Prices $790.00
Sizes 96 t
Sensitivity 0.059ng/mL
Range 0.156-10ng/mL

Nucleoside diphosphate kinase A (NME1), Human, ELISA Kit - CSB-EL015884HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 4.68 pg/ml
Range 18.75 pg/ml-1200 pg/ml

Nucleoside diphosphate kinase A, NME1, Human, ELISA Kit - E14300h from ARP American Research Products

Category ELISA Kit
Prices $736.00
Sizes 96 t
Range 0.156-10 ng/mL

NME1 (Human) IP-WB Antibody Pair - H00004830-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

NME1 (Human) Matched Antibody Pair - H00004830-AP11 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS105472 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS082961 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS066324 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS099353 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS088625 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS050750 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS066370 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS055388 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS098913 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS101217 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS099946 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS048751 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS083312 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS047474 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS087435 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS090783 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS083367 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit - MBS099774 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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