NME1

Gene Symbol	NME1
Entrez Gene	4830
Alt Symbol	AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1
Species	Human
Gene Type	protein-coding
Description	NME/NM23 nucleoside diphosphate kinase 1
Other Description	NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|non-metastatic cells 1, protein (NM23A) expressed in|nucleoside diphosphate kinase A|tumor metastatic process-associated protein
Swissprots	Q86XQ2 Q6FGK3 P15531 Q9UDJ6
Accessions	CAA53270 EAW94568 P15531 AF487339 AAO85436 AK291105 BAF83794 AK309160 AL360166 AL360191 BC000293 AAH00293 BC018994 AAH18994 BE727815 BF965472 BG531372 BG715560 BG757842 BI666785 BM479520 BU600979 CR542104 CAG46901 CR542115 CAG46912 D28367 BAA05733 S68891 X17620 CAA35621 X73066 CAA51527 NM_000269 NP_000260 NM_198175 NP_937818
Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Tissue Specificity	Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10512675, ECO:0000269|PubMed:12601555, ECO:0000269|PubMed:16442775}.
Top Pathways	Purine metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NM23A full length protein - ab87667 from Abcam Category Protein Source E. coli Species Human

NM23A peptide - ab88971 from Abcam Category Peptide

NBL1 / DAN Antibody Blocking Peptide - LS-E20589 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NME1 / NM23 Antibody Blocking Peptide - LS-E3821 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NME1 / NM23 Antibody Blocking Peptide - LS-E3731 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NME1 / NM23 Antibody Blocking Peptide - LS-E10599 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NME1 / NM23 Antibody Blocking Peptide - LS-E13707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NME1 / NM23 Antibody Blocking Peptide - LS-E9477 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NM23-H1 Protein - H00004830-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NM23-H1 Partial Recombinant Protein - H00004830-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NM23-H1 Protein - NBP1-30195 from Novus Biologicals Category Protein Species Human

NM23-H1 Peptide - P3076 from Novus Biologicals Category Peptide Species Human

NME1-Antibody-Center-Blocking-Peptide - BP16000c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NME1-Antibody-C-term-Blocking-Peptide - BP14941b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NM23-NME1-Antibody-N-term-Blocking-peptide - BP8080a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Nucleoside diphosphate kinase A (OPCA00477) - OPCA00477 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

NME1 Protein (OPPA01865) - OPPA01865 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human NME1 protein - orb245151 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human NM23H1 protein - orb49566 from Biorbyt Category Protein Prices $366.00, $706.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

nucleoside diphosphate kinase A protein - orb197652 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00, $1,556.00 Sizes 10 μg, 50 μg, 100 μg, 500 μg Species Human

Human Non-Metastatic Cells 1 protein - orb81236 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human NME1 His tag protein - orb83869 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

NME1 Blocking Peptide - 33R-1394 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NME1 protein - 30R-3124 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

NME1 protein - 30R-1361 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

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