| Gene Symbol | NME1 |
|---|---|
| Entrez Gene | 4830 |
| Alt Symbol | AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NME/NM23 nucleoside diphosphate kinase 1 |
| Other Description | NDP kinase A|granzyme A-activated DNase|metastasis inhibition factor nm23|non-metastatic cells 1, protein (NM23A) expressed in|nucleoside diphosphate kinase A|tumor metastatic process-associated protein |
| Swissprots | Q86XQ2 Q6FGK3 P15531 Q9UDJ6 |
| Accessions | CAA53270 EAW94568 P15531 AF487339 AAO85436 AK291105 BAF83794 AK309160 AL360166 AL360191 BC000293 AAH00293 BC018994 AAH18994 BE727815 BF965472 BG531372 BG715560 BG757842 BI666785 BM479520 BU600979 CR542104 CAG46901 CR542115 CAG46912 D28367 BAA05733 S68891 X17620 CAA35621 X73066 CAA51527 NM_000269 NP_000260 NM_198175 NP_937818 |
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. |
| Tissue Specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10512675, ECO:0000269|PubMed:12601555, ECO:0000269|PubMed:16442775}. |
| Top Pathways | Purine metabolism, Pyrimidine metabolism |