| Gene Symbol | PABPC4 |
|---|---|
| Entrez Gene | 8761 |
| Alt Symbol | APP-1, APP1, PABP4, iPABP |
| Species | Human |
| Gene Type | protein-coding |
| Description | poly(A) binding protein, cytoplasmic 4 (inducible form) |
| Other Description | PABP-4|activated-platelet protein 1|inducible poly(A)-binding protein|poly(A)-binding protein 4|polyadenylate-binding protein 4 |
| Swissprots | Q6P0N3 B1ANQ8 Q13310 Q4VC03 |
| Accessions | EAX07261 EAX07262 EAX07263 EAX07264 EAX07265 EAX07266 EAX07267 EAX07268 Q13310 AB208962 BAD92199 AK091110 AK125926 AK222917 BAD96637 BC029969 BC065540 AAH65540 BC071591 AAH71591 BC094755 AAH94755 BC106908 AAI06909 BC118568 AAI18569 D12799 BAA02244 DB455681 U33818 AAC50350 U75686 AAB97309 NM_001135653 NP_001129125 NM_001135654 NP_001129126 NM_003819 NP_003810 |
| Function | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Tissue Specificity | Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. |
| Top Pathways | RNA degradation, RNA transport, mRNA surveillance pathway |