Gene Symbol | PABPC4 |
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Entrez Gene | 8761 |
Alt Symbol | APP-1, APP1, PABP4, iPABP |
Species | Human |
Gene Type | protein-coding |
Description | poly(A) binding protein, cytoplasmic 4 (inducible form) |
Other Description | PABP-4|activated-platelet protein 1|inducible poly(A)-binding protein|poly(A)-binding protein 4|polyadenylate-binding protein 4 |
Swissprots | Q6P0N3 B1ANQ8 Q13310 Q4VC03 |
Accessions | EAX07261 EAX07262 EAX07263 EAX07264 EAX07265 EAX07266 EAX07267 EAX07268 Q13310 AB208962 BAD92199 AK091110 AK125926 AK222917 BAD96637 BC029969 BC065540 AAH65540 BC071591 AAH71591 BC094755 AAH94755 BC106908 AAI06909 BC118568 AAI18569 D12799 BAA02244 DB455681 U33818 AAC50350 U75686 AAB97309 NM_001135653 NP_001129125 NM_001135654 NP_001129126 NM_003819 NP_003810 |
Function | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
Tissue Specificity | Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. |
Top Pathways | RNA degradation, RNA transport, mRNA surveillance pathway |
PABPC4 CRISPR/Cas9 KO Plasmid (h) - sc-411206 from Santa Cruz Biotechnology
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PABPC4 HDR Plasmid (h) - sc-411206-HDR from Santa Cruz Biotechnology
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PABPC4 Double Nickase Plasmid (h) - sc-411206-NIC from Santa Cruz Biotechnology
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PABPC4 Double Nickase Plasmid (h2) - sc-411206-NIC-2 from Santa Cruz Biotechnology
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PABPC4 CRISPR Activation Plasmid (h) - sc-411206-ACT from Santa Cruz Biotechnology
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PABPC4 CRISPR Activation Plasmid (h2) - sc-411206-ACT-2 from Santa Cruz Biotechnology
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PABPC4 Lentiviral Activation Particles (h) - sc-411206-LAC from Santa Cruz Biotechnology
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PABPC4 Lentiviral Activation Particles (h2) - sc-411206-LAC-2 from Santa Cruz Biotechnology
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PABPC4 siRNA (h) - sc-106347 from Santa Cruz Biotechnology
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PABPC4 shRNA Plasmid (h) - sc-106347-SH from Santa Cruz Biotechnology
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PABPC4 shRNA (h) Lentiviral Particles - sc-106347-V from Santa Cruz Biotechnology
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PABPC4 RNAi - H00008761-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16252 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16252 from Sigma-Aldrich
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PABPC4 siRNA (Human) - CRH5771 from Cohesion Biosciences
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shRNA set against Human PABPC4 (NM_003819.3) - SHH369780 from Creative biogene
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Human PABPC4 siRNA - orb266273 from Biorbyt
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PABPC4 shRNA Plasmid (Human) - CHH5771 from Cohesion Biosciences
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PABPC4 miRNA 3'UTR clone - MiUTR3H-05942 from Creative biogene
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PABPC4 miRNA 3'UTR clone - MiUTR3H-05943 from Creative biogene
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PABPC4 miRNA 3'UTR clone - MiUTR3H-05944 from Creative biogene
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