| Gene Symbol |
ELF3
|
| Entrez Gene |
1999
|
| Alt Symbol |
EPR-1, ERT, ESE-1, ESX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
|
| Other Description |
E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)|E74-like factor 3 (ets domain transcription factor)|ETS-related transcription factor Elf-3|epithelial-restricted with serine box|epithelium-restricted Ets protein ESX|epithelium-specific Ets transcription factor 1|ets domain transcription factor, serine box (epithelial-specific)
|
| Swissprots |
P78545 Q6IAP8 Q8NFG2 Q7Z3X2 B2R5Q6 Q99718 Q7RU03
|
| Accessions |
AAD45237 CAD29859 EAW91388 EAW91389 EAW91390 EAW91391 P78545 AF016295 AAB96586 AF017307 AAB67238 AF517841 AAM70481 AK225446 AK309265 AK310814 AK312273 BAG35203 BC003569 AAH03569 BM976796 BQ023145 BX093212 BX537368 CAD97611 CR457106 CAG33387 CV570925 CV570991 DA591406 DQ890691 ABM81617 DQ893874 ABM84800 U66894 AAB58075 U73843 AAB65823 U73844 AAB65824 U97156 AAC51884 XM_005244942 XP_005244999 NM_001114309 NP_001107781 NM_004433 NP_004424
|
| Function |
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}.
|
| Tissue Specificity |
Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. {ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241}.
|