ELF3

Gene Symbol	ELF3
Entrez Gene	1999
Alt Symbol	EPR-1, ERT, ESE-1, ESX
Species	Human
Gene Type	protein-coding
Description	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
Other Description	E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)|E74-like factor 3 (ets domain transcription factor)|ETS-related transcription factor Elf-3|epithelial-restricted with serine box|epithelium-restricted Ets protein ESX|epithelium-specific Ets transcription factor 1|ets domain transcription factor, serine box (epithelial-specific)
Swissprots	P78545 Q6IAP8 Q8NFG2 Q7Z3X2 B2R5Q6 Q99718 Q7RU03
Accessions	AAD45237 CAD29859 EAW91388 EAW91389 EAW91390 EAW91391 P78545 AF016295 AAB96586 AF017307 AAB67238 AF517841 AAM70481 AK225446 AK309265 AK310814 AK312273 BAG35203 BC003569 AAH03569 BM976796 BQ023145 BX093212 BX537368 CAD97611 CR457106 CAG33387 CV570925 CV570991 DA591406 DQ890691 ABM81617 DQ893874 ABM84800 U66894 AAB58075 U73843 AAB65823 U73844 AAB65824 U97156 AAC51884 XM_005244942 XP_005244999 NM_001114309 NP_001107781 NM_004433 NP_004424
Function	Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}.
Tissue Specificity	Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin. {ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ESE1 peptide - ab135437 from Abcam Category Peptide Prices $285.00 Sizes 100 µg

Human ESE1 full length protein - ab131849 from Abcam Category Protein Source Wheat germ Species Human

Human ESE1 peptide - ab22940 from Abcam Category Peptide Species Human

Human ESE1 protein fragment - ab114718 from Abcam Category Protein Source Wheat germ Species Human

ELF3 / ESE1 Antibody Blocking Peptide - LS-E25380 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF3 / ESE1 Antibody Blocking Peptide - LS-E13208 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF3 / ESE1 Antibody Blocking Peptide - LS-E11268 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF3 / ESE1 Antibody Blocking Peptide - LS-E11056 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF3 / ESE1 Antibody Blocking Peptide - LS-E10133 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ELF3/ESE-1 Partial Recombinant Protein - H00001999-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ELF3/ESE-1 Protein - H00001999-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ELF3-Antibody-C-term-Blocking-Peptide - BP9441b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ESE1 blocking peptide - GTX89904-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Goat anti ELF3 antibody Immunizing peptide - orb17688 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ESE1 Peptide - AC21-0208-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ELF3 / ESE-1 - H00001999-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ELF3 / ESE-1 - H00001999-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ELF3 / ESE-1 - H00001999-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ELF3 / ESE-1 - H00001999-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ELF3 Peptide - 45-527P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

ELF3 Peptide - 350550 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human ELF3 - ELF3-27972TH from Creative Biomart Category Protein Source Wheat germ

Recombinant 6 kDa early secretory antigenic target homolog(esxA) - CSB-YP706488MVN CSB-EP706488MVN CSB-BP706488MVN CSB-MP706488MVN from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mycobacterium

Recombinant Human ETS-related transcription factor Elf-3(ELF3) - CSB-YP007598HU CSB-EP007598HU CSB-BP007598HU CSB-MP007598HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ELF3 / ESE-1 (transcript variant 1) - TP300631 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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