Gene Symbol | KRTAP12-4 |
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Entrez Gene | 386684 |
Alt Symbol | KRTAP12.4 |
Species | Human |
Gene Type | protein-coding |
Description | keratin associated protein 12-4 |
Other Description | high sulfur keratin-associated protein 12.4|keratin-associated protein 12-4 |
Swissprots | Q08AF5 P60329 |
Accessions | EAX09408 P60329 AB076360 BAD01547 BC125198 AAI25199 NM_198698 NP_941971 |
Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. |
Tissue Specificity | Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}. |
KRTAP12-4 CRISPR/Cas9 KO Plasmid (h) - sc-415734 from Santa Cruz Biotechnology
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KRTAP12-4 HDR Plasmid (h) - sc-415734-HDR from Santa Cruz Biotechnology
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KRTAP12-4 Double Nickase Plasmid (h) - sc-415734-NIC from Santa Cruz Biotechnology
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KRTAP12-4 Double Nickase Plasmid (h2) - sc-415734-NIC-2 from Santa Cruz Biotechnology
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KRTAP12-4 CRISPR Activation Plasmid (h) - sc-415734-ACT from Santa Cruz Biotechnology
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KRTAP12-4 CRISPR Activation Plasmid (h2) - sc-415734-ACT-2 from Santa Cruz Biotechnology
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KRTAP12-4 Lentiviral Activation Particles (h) - sc-415734-LAC from Santa Cruz Biotechnology
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KRTAP12-4 Lentiviral Activation Particles (h2) - sc-415734-LAC-2 from Santa Cruz Biotechnology
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KRTAP12-4 siRNA (h) - sc-91502 from Santa Cruz Biotechnology
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KRTAP12-4 shRNA Plasmid (h) - sc-91502-SH from Santa Cruz Biotechnology
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KRTAP12-4 shRNA (h) Lentiviral Particles - sc-91502-V from Santa Cruz Biotechnology
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KRTAP12-4 RNAi - H00386684-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11431 from Sigma-Aldrich
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KRTAP12-4 siRNA (Human) - CRJ7720 from Cohesion Biosciences
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shRNA set against Human KRTAP12-4(NM_198698.1) - SHH138791 from Creative biogene
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Human KRTAP12-4 siRNA - orb278221 from Biorbyt
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KRTAP12-4 shRNA Plasmid (Human) - CHJ7720 from Cohesion Biosciences
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KRTAP12-4 miRNA 3'UTR clone - MiUTR1H-05490 from Creative biogene
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