Gene Symbol | ABHD4 |
---|---|
Entrez Gene | 63874 |
Alt Symbol | ABH4 |
Species | Human |
Gene Type | protein-coding |
Description | abhydrolase domain containing 4 |
Other Description | abhydrolase domain-containing protein 4|alpha/beta-hydrolase 4|lyso-N-acylphosphatidylethanolamine lipase |
Swissprots | Q9H9E0 Q8TB40 B4DDH7 |
Accessions | EAW66251 Q8TB40 AK022878 BAB14289 AK024790 AK293198 BAG56738 AK298127 BAG60407 AK301315 BAG62866 BC024779 AAH24779 XM_005267986 XP_005268043 XR_245712 NM_022060 NP_071343 |
Function | Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity). {ECO:0000250}. |