Gene Symbol | ABHD4 |
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Entrez Gene | 63874 |
Alt Symbol | ABH4 |
Species | Human |
Gene Type | protein-coding |
Description | abhydrolase domain containing 4 |
Other Description | abhydrolase domain-containing protein 4|alpha/beta-hydrolase 4|lyso-N-acylphosphatidylethanolamine lipase |
Swissprots | Q9H9E0 Q8TB40 B4DDH7 |
Accessions | EAW66251 Q8TB40 AK022878 BAB14289 AK024790 AK293198 BAG56738 AK298127 BAG60407 AK301315 BAG62866 BC024779 AAH24779 XM_005267986 XP_005268043 XR_245712 NM_022060 NP_071343 |
Function | Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity). {ECO:0000250}. |
ABHD4 CRISPR/Cas9 KO Plasmid (h) - sc-406748 from Santa Cruz Biotechnology
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ABHD4 HDR Plasmid (h) - sc-406748-HDR from Santa Cruz Biotechnology
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ABHD4 Double Nickase Plasmid (h) - sc-406748-NIC from Santa Cruz Biotechnology
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ABHD4 Double Nickase Plasmid (h2) - sc-406748-NIC-2 from Santa Cruz Biotechnology
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ABHD4 CRISPR Activation Plasmid (h) - sc-406748-ACT from Santa Cruz Biotechnology
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ABHD4 CRISPR Activation Plasmid (h2) - sc-406748-ACT-2 from Santa Cruz Biotechnology
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ABHD4 Lentiviral Activation Particles (h) - sc-406748-LAC from Santa Cruz Biotechnology
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ABHD4 Lentiviral Activation Particles (h2) - sc-406748-LAC-2 from Santa Cruz Biotechnology
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ABHD4 siRNA (h) - sc-92382 from Santa Cruz Biotechnology
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ABHD4 shRNA Plasmid (h) - sc-92382-SH from Santa Cruz Biotechnology
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ABHD4 shRNA (h) Lentiviral Particles - sc-92382-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU037171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2665 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2665 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09342 from Sigma-Aldrich
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ABHD4 siRNA (Human) - CRJ1840 from Cohesion Biosciences
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ABHD4 - MBS828662 from MyBioSource
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shRNA set against Human ABHD4 (NM_022060.2) - SHH229526 from Creative biogene
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Human ABHD4 siRNA - orb272341 from Biorbyt
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ABHD4 shRNA Plasmid (Human) - CHJ1840 from Cohesion Biosciences
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ABHD4 miRNA 3'UTR clone - MiUTR1H-00066 from Creative biogene
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