| Gene Symbol |
GIMAP4
|
| Entrez Gene |
55303
|
| Alt Symbol |
IAN-1, IAN1, IMAP4, MSTP062
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GTPase, IMAP family member 4
|
| Other Description |
GTPase IMAP family member 4|human immune associated nucleotide 1|immune-associated nucleotide-binding protein 1|immunity associated protein 4|immunity-associated nucleotide 1 protein|immunity-associated protein 4
|
| Swissprots |
Q9NUV9
|
| Accessions |
CAH05343 EAL24482 EAW54103 EAW54104 Q9NUV9 AF117333 AAO15308 AJ227872 AK001972 BAA92010 AK301441 BAG62967 AK301606 BAG63092 AW836736 BC020657 AAH20657 BC020776 BX476689 HQ447690 ADQ32175 XM_005250017 XP_005250074 NM_018326 NP_060796
|
| Function |
May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:23454188}.
|
| Tissue Specificity |
Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine. {ECO:0000269|PubMed:23454188}.
|
![Western Blot: GIMAP4 Overexpression Lysate (Adult Normal) [NBL1-11073] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GIMAP4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/7916_GIMAP4%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-11073-img0002.jpg)