Gene Symbol | GIMAP4 |
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Entrez Gene | 55303 |
Alt Symbol | IAN-1, IAN1, IMAP4, MSTP062 |
Species | Human |
Gene Type | protein-coding |
Description | GTPase, IMAP family member 4 |
Other Description | GTPase IMAP family member 4|human immune associated nucleotide 1|immune-associated nucleotide-binding protein 1|immunity associated protein 4|immunity-associated nucleotide 1 protein|immunity-associated protein 4 |
Swissprots | Q9NUV9 |
Accessions | CAH05343 EAL24482 EAW54103 EAW54104 Q9NUV9 AF117333 AAO15308 AJ227872 AK001972 BAA92010 AK301441 BAG62967 AK301606 BAG63092 AW836736 BC020657 AAH20657 BC020776 BX476689 HQ447690 ADQ32175 XM_005250017 XP_005250074 NM_018326 NP_060796 |
Function | May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:23454188}. |
Tissue Specificity | Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine. {ECO:0000269|PubMed:23454188}. |
GIMAP4 CRISPR/Cas9 KO Plasmid (h) - sc-408107 from Santa Cruz Biotechnology
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GIMAP4 HDR Plasmid (h) - sc-408107-HDR from Santa Cruz Biotechnology
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GIMAP4 Double Nickase Plasmid (h) - sc-408107-NIC from Santa Cruz Biotechnology
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GIMAP4 Double Nickase Plasmid (h2) - sc-408107-NIC-2 from Santa Cruz Biotechnology
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GIMAP4 CRISPR Activation Plasmid (h) - sc-408107-ACT from Santa Cruz Biotechnology
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GIMAP4 CRISPR Activation Plasmid (h2) - sc-408107-ACT-2 from Santa Cruz Biotechnology
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GIMAP4 Lentiviral Activation Particles (h) - sc-408107-LAC from Santa Cruz Biotechnology
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GIMAP4 Lentiviral Activation Particles (h2) - sc-408107-LAC-2 from Santa Cruz Biotechnology
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GIMAP4 siRNA (h) - sc-89794 from Santa Cruz Biotechnology
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GIMAP4 shRNA Plasmid (h) - sc-89794-SH from Santa Cruz Biotechnology
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GIMAP4 shRNA (h) Lentiviral Particles - sc-89794-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9285 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9285 from Sigma-Aldrich
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GIMAP4 siRNA (Human) - CRJ0641 from Cohesion Biosciences
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GIMAP4 RNAi - H00055303-R01 from Novus Biologicals
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GIMAP4 - MBS8201214 from MyBioSource
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shRNA set against Human GIMAP4 (NM_018326.2) - SHH301066 from Creative biogene
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shRNA set against Human GIMAP4(NM_018326.2) - SHH084449 from Creative biogene
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GIMAP4 shRNA Plasmid (Human) - CHJ0641 from Cohesion Biosciences
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GIMAP4 miRNA 3'UTR clone - MiUTR1H-04034 from Creative biogene
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