| Gene Symbol |
USP6NL
|
| Entrez Gene |
9712
|
| Alt Symbol |
RNTRE, TRE2NL, USP6NL-IT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
USP6 N-terminal like
|
| Other Description |
USP6 N-terminal-like protein|related to the N-terminus of tre
|
| Swissprots |
A8KA79 Q5VV10 Q7L0K9 Q15400 Q92738
|
| Accessions |
EAW86344 Q92738 AA741061 AB449916 BAH16659 AK091487 AK292944 BAF85633 AK311094 AK311453 AM392670 CAL37548 AM393098 CAL37976 AM393366 CAL38244 AM393656 CAL38532 BC010351 AAH10351 BC042943 AAH42943 CF121539 D13644 BAA02807 DB457665 HY012494 XM_006717542 XP_006717605 XM_011519762 XP_011518064 XM_011519763 XP_011518065 XM_011519764 XP_011518066 NM_001080491 NP_001073960 NM_014688 NP_055503 NR_125732
|
| Function |
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}.
|
| Subcellular Location |
Golgi apparatus. Cytoplasmic vesicle.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8700515}.
|