| Gene Symbol |
RAPGEF3
|
| Entrez Gene |
10411
|
| Alt Symbol |
CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rap guanine nucleotide exchange factor (GEF) 3
|
| Other Description |
9330170P05Rik|EPAC 1|Rap1 guanine-nucleotide-exchange factor directly activated by cAMP|cAMP-regulated guanine nucleotide exchange factor I|exchange factor directly activated by cAMP 1|exchange protein directly activated by cAMP 1|rap guanine nucleotide exchange factor 3
|
| Swissprots |
Q8WVN0 E7EQC8 A8K2G5 O95398 O95634
|
| Accessions |
CAL48169 EAW57944 EAW57945 EAW57946 EAW57947 EAW57948 EAW57949 O95398 AF103905 AAC83381 AK055502 BAG51527 AK074444 AK092448 AK125545 BAG54212 AK290230 BAF82919 AK299029 BAH12932 AK308079 BC017728 AAH17728 BC040534 BC068477 BC092404 AAH92404 BQ007070 CN294139 DA340363 DA529158 DA629958 DB179165 DB278856 DQ891561 ABM82487 DQ894748 ABM85674 U78168 AAD12740 U78169 AAD02890 U79275 AAB50216 XM_005268571 XP_005268628 XM_011537751 XP_011536053 XM_011537752 XP_011536054 XM_011537753 XP_011536055 XM_011537754 XP_011536056 XM_011537755 XP_011536057 XM_011537756 XP_011536058 XM_011537757 XP_011536059 XM_011537758 XP_011536060 XM_011537759 XP_011536061 XR_944480 NM_001098531 NP_001092001 NM_001098532 NP_001092002 NM_006105 NP_006096
|
| Function |
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:10777494}.
|
| Tissue Specificity |
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. {ECO:0000269|PubMed:9856955}.
|
| Top Pathways |
Leukocyte transendothelial migration, Long-term potentiation, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Rap1 signaling pathway
|