SMG6

Gene Symbol SMG6
Entrez Gene 23293
Alt Symbol C17orf31, EST1A, SMG-6, hSMG5/7a
Species Human
Gene Type protein-coding
Description SMG6 nonsense mediated mRNA decay factor
Other Description EST1 telomerase component homolog A|ever shorter telomeres 1A|smg-6 homolog, nonsense mediated mRNA decay factor|telomerase subunit EST1A|telomerase-binding protein EST1A
Swissprots Q86VH6 B7Z874 Q86US8 Q9UF60 O94837
Accessions CAH05610 EAW90557 EAW90559 Q86US8 AB018275 BAA34452 AK024131 BAB14835 AK074270 AK093007 AK302964 BAH13860 AL080204 AL133597 CAB63733 AU120859 AY145883 AAN46114 AY168921 AAO17581 BC064916 AAH64916 BC148373 AAI48374 DB333407 XM_005256569 XP_005256626 XM_005256570 XP_005256627 XM_005256571 XP_005256628 XM_006721494 XP_006721557 XM_006721495 XP_006721558 XM_011523769 XP_011522071 XM_011523770 XP_011522072 XM_011523771 XP_011522073 XM_011523772 XP_011522074 XM_011523773 XP_011522075 XM_011523774 XP_011522076 XM_011523775 XP_011522077 NM_001256827 NP_001243756 NM_001256828 NP_001243757 NM_001282326 NP_001269255 NM_017575 NP_060045 NM_001170957
Function Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'- (GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).
Subcellular Location Nucleus, nucleolus. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629}.
Top Pathways mRNA surveillance pathway

SMG6 CRISPR/Cas9 KO Plasmid (h) - sc-411705 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 HDR Plasmid (h) - sc-411705-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 Double Nickase Plasmid (h) - sc-411705-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 Double Nickase Plasmid (h2) - sc-411705-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 CRISPR Activation Plasmid (h) - sc-411705-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 CRISPR Activation Plasmid (h2) - sc-411705-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 Lentiviral Activation Particles (h) - sc-411705-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 Lentiviral Activation Particles (h2) - sc-411705-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG6 siRNA (h) - sc-61569 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMG6 shRNA Plasmid (h) - sc-61569-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMG6 shRNA (h) Lentiviral Particles - sc-61569-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMG6 RNAi - H00023293-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU003801 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19791 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19791 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SMG6 siRNA (Human) - CRH8156 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMG6 - MBS8200903 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMG6 (NM_017575.4) - SHH413424 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SMG6(NM_017575.4) - SHL018710 from Creative biogene

Category siRNA
Species Reactivities Human

SMG6 shRNA Plasmid (Human) - CHH8156 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMG6 miRNA 3'UTR clone - MiUTR1H-09661 from Creative biogene

Species Reactivities Human
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