SMG6

Gene Symbol SMG6
Entrez Gene 23293
Alt Symbol C17orf31, EST1A, SMG-6, hSMG5/7a
Species Human
Gene Type protein-coding
Description SMG6 nonsense mediated mRNA decay factor
Other Description EST1 telomerase component homolog A|ever shorter telomeres 1A|smg-6 homolog, nonsense mediated mRNA decay factor|telomerase subunit EST1A|telomerase-binding protein EST1A
Swissprots Q86VH6 B7Z874 Q86US8 Q9UF60 O94837
Accessions CAH05610 EAW90557 EAW90559 Q86US8 AB018275 BAA34452 AK024131 BAB14835 AK074270 AK093007 AK302964 BAH13860 AL080204 AL133597 CAB63733 AU120859 AY145883 AAN46114 AY168921 AAO17581 BC064916 AAH64916 BC148373 AAI48374 DB333407 XM_005256569 XP_005256626 XM_005256570 XP_005256627 XM_005256571 XP_005256628 XM_006721494 XP_006721557 XM_006721495 XP_006721558 XM_011523769 XP_011522071 XM_011523770 XP_011522072 XM_011523771 XP_011522073 XM_011523772 XP_011522074 XM_011523773 XP_011522075 XM_011523774 XP_011522076 XM_011523775 XP_011522077 NM_001256827 NP_001243756 NM_001256828 NP_001243757 NM_001282326 NP_001269255 NM_017575 NP_060045 NM_001170957
Function Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'- (GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).
Subcellular Location Nucleus, nucleolus. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629}.
Top Pathways mRNA surveillance pathway

SMG6 (P-18)-R - sc-50984-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

Anti-EST1A antibody - ab87539 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EST1A antibody (ab87539) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Nuclear Lysate (ab14844)Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Nuclear LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

SMG6 Antibody - NBP1-92410 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-EST1A Polyclonal Antibody - bs-6527R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-EST1A Polyclonal Antibody, Unconjugated (bs-6527R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-SMG6 antibody produced in rabbit - HPA042932 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SMG6: <B>Cat. No. HPA042932</B>: Immunohistochemical staining of human cerebellum shows distinct cytoplasmic and nucleolar/ nuclear positivity in Purkinje cells.

EST1A Antibody - middle region (ARP75465_P050) - ARP75465_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMG6 antibody - H00023293-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

SMG6 Antibody - abx122219 from Abbexa

Host Rabbit
Clonality Polyclonal

SMG6 Antibody,Biotin conjugated - CSB-PA773032LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SMG6 Antibody,FITC conjugated - CSB-PA773032LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SMG6 Antibody,HRP conjugated - CSB-PA773032LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SMG6 Antibody - CSB-PA773032LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal

EST1A antibody (FITC) - orb102551 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

SMG6 Polyclonal Antibody - A10141 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cells, using SMG6 antibody.

SMG6 Antibody - abx136051 from Abbexa

Host Rabbit
Clonality Polyclonal

SMG6 - A10141 from NeoScientific

Prices $220.00, $380.00
Sizes 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMG6 antibody - STJ112180 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

SMG6 Polyclonal Antibody - A10141 from ARP American Research Products

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Clonality Polyclonal

EST1A Antibody - middle region : Biotin (ARP75465_P050-Biotin) - ARP75465_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

EST1A Antibody - middle region : FITC (ARP75465_P050-FITC) - ARP75465_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

EST1A Antibody - middle region : HRP (ARP75465_P050-HRP) - ARP75465_P050-HRP from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

Anti-SMG6 Antibody - LS-C496853 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SMG6 Antibody (FITC) - LS-C398977 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SMG6 Antibody (HRP) - LS-C398986 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SMG6 Antibody (Biotin) - LS-C398987 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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