| Gene Symbol |
SLC24A5
|
| Entrez Gene |
283652
|
| Alt Symbol |
JSX, NCKX5, OCA6, SHEP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
|
| Other Description |
Na(+)/K(+)/Ca(2+)-exchange protein 5|ion transporter JSX|oculocutaneous albinism 6 (autosomal recessive)|sodium/potassium/calcium exchanger 5|solute carrier family 24, member 5
|
| Swissprots |
A5X8Z8 Q14CT4 Q6DKH3 Q71RS6 A5X8Z9
|
| Accessions |
EAW77335 Q71RS6 AF348468 AAQ15116 BC073944 AAH73944 BC110836 BC113628 AAI13629 BC113630 AAI13631 BC143950 AAI43951 DQ665306 ABG66958 DQ665307 ABG66959 HQ258279 ADR83033 XM_011521458 XP_011519760 NM_205850 NP_995322
|
| Function |
Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). {ECO:0000269|PubMed:16357253, ECO:0000269|PubMed:18166528}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes.
|