Gene Symbol | SLC24A5 |
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Entrez Gene | 283652 |
Alt Symbol | JSX, NCKX5, OCA6, SHEP4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 |
Other Description | Na(+)/K(+)/Ca(2+)-exchange protein 5|ion transporter JSX|oculocutaneous albinism 6 (autosomal recessive)|sodium/potassium/calcium exchanger 5|solute carrier family 24, member 5 |
Swissprots | A5X8Z8 Q14CT4 Q6DKH3 Q71RS6 A5X8Z9 |
Accessions | EAW77335 Q71RS6 AF348468 AAQ15116 BC073944 AAH73944 BC110836 BC113628 AAI13629 BC113630 AAI13631 BC143950 AAI43951 DQ665306 ABG66958 DQ665307 ABG66959 HQ258279 ADR83033 XM_011521458 XP_011519760 NM_205850 NP_995322 |
Function | Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). {ECO:0000269|PubMed:16357253, ECO:0000269|PubMed:18166528}. |
Subcellular Location | Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes. |
NCKX5 CRISPR/Cas9 KO Plasmid (h) - sc-405875 from Santa Cruz Biotechnology
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NCKX5 HDR Plasmid (h) - sc-405875-HDR from Santa Cruz Biotechnology
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NCKX5 Double Nickase Plasmid (h) - sc-405875-NIC from Santa Cruz Biotechnology
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NCKX5 Double Nickase Plasmid (h2) - sc-405875-NIC-2 from Santa Cruz Biotechnology
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NCKX5 CRISPR Activation Plasmid (h) - sc-405875-ACT from Santa Cruz Biotechnology
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NCKX5 CRISPR Activation Plasmid (h2) - sc-405875-ACT-2 from Santa Cruz Biotechnology
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NCKX5 Lentiviral Activation Particles (h) - sc-405875-LAC from Santa Cruz Biotechnology
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NCKX5 Lentiviral Activation Particles (h2) - sc-405875-LAC-2 from Santa Cruz Biotechnology
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NCKX5 siRNA (h) - sc-90252 from Santa Cruz Biotechnology
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NCKX5 shRNA Plasmid (h) - sc-90252-SH from Santa Cruz Biotechnology
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NCKX5 shRNA (h) Lentiviral Particles - sc-90252-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19481 from Sigma-Aldrich
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SLC24A5 siRNA (Human) - CRJ6927 from Cohesion Biosciences
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SLC24A5 - MBS8212282 from MyBioSource
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shRNA set against Human SLC24A5 (NM_205850.2) - SHH409356 from Creative biogene
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shRNA set against Human SLC24A5(NM_205850.2) - SHL001950 from Creative biogene
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NCKX5 CRISPR/Cas9 KO Plasmid (h2) - sc-405875-KO-2 from Santa Cruz Biotechnology
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NCKX5 HDR Plasmid (h2) - sc-405875-HDR-2 from Santa Cruz Biotechnology
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Human SLC24A5 siRNA - orb277428 from Biorbyt
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SLC24A5 shRNA Plasmid (Human) - CHJ6927 from Cohesion Biosciences
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SLC24A5 miRNA 3'UTR clone - MiUTR1H-09471 from Creative biogene
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