Gene Symbol | COL17A1 |
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Entrez Gene | 1308 |
Alt Symbol | BA16H23.2, BP180, BPA-2, BPAG2, LAD-1 |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type XVII, alpha 1 |
Other Description | 180 kDa bullous pemphigoid antigen 2|alpha 1 type XVII collagen|bA16H23.2 (collagen, type XVII, alpha 1 (BP180))|bullous pemphigoid antigen 2 (180kD)|collagen XVII, alpha-1 polypeptide|collagen alpha-1(XVII) chain|type XVII collagen alpha-1 |
Swissprots | Q9NQK9 Q9UC14 Q9UMD9 Q99018 Q5JV36 Q02802 |
Accessions | AAB51499 EAW49612 EAW49613 EAW49614 Q9UMD9 AB900157 BAO31681 AF136185 AF136186 AK309940 AU076442 BC004478 AAH04478 BC168368 AAI68368 D63465 M63730 AAA51839 M91669 AAA35605 NM_000494 NP_000485 NM_130778 |
Function | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. |
Subcellular Location | 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Localized in the lamina lucida beneath the hemidesmosomes. |
Tissue Specificity | Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves. {ECO:0000269|PubMed:1748679, ECO:0000269|PubMed:8618013}. |
Top Pathways | Protein digestion and absorption |
COL17A1 CRISPR/Cas9 KO Plasmid (h) - sc-402747 from Santa Cruz Biotechnology
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COL17A1 HDR Plasmid (h) - sc-402747-HDR from Santa Cruz Biotechnology
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COL17A1 Double Nickase Plasmid (h) - sc-402747-NIC from Santa Cruz Biotechnology
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COL17A1 Double Nickase Plasmid (h2) - sc-402747-NIC-2 from Santa Cruz Biotechnology
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COL17A1 CRISPR Activation Plasmid (h) - sc-402747-ACT from Santa Cruz Biotechnology
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COL17A1 CRISPR Activation Plasmid (h2) - sc-402747-ACT-2 from Santa Cruz Biotechnology
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COL17A1 Lentiviral Activation Particles (h) - sc-402747-LAC from Santa Cruz Biotechnology
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COL17A1 Lentiviral Activation Particles (h2) - sc-402747-LAC-2 from Santa Cruz Biotechnology
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COL17A1 siRNA (h) - sc-43070 from Santa Cruz Biotechnology
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COL17A1 shRNA Plasmid (h) - sc-43070-SH from Santa Cruz Biotechnology
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COL17A1 shRNA (h) Lentiviral Particles - sc-43070-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU139651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6374 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6374 from Sigma-Aldrich
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COL17A1 siRNA (Human) - CRH0921 from Cohesion Biosciences
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COL17A1 - MBS8204334 from MyBioSource
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shRNA set against Human COL17A1(NM_000494.3) - SHG189635 from Creative biogene
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Human Collagen alpha-1(XVII) chain siRNA - orb261423 from Biorbyt
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COL17A1 shRNA Plasmid (Human) - CHH0921 from Cohesion Biosciences
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COL17A1 miRNA 3'UTR clone - MiUTR1H-02306 from Creative biogene
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