Gene Symbol | CHST12 |
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Entrez Gene | 55501 |
Alt Symbol | C4S-2, C4ST-2, C4ST2 |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (chondroitin 4) sulfotransferase 12 |
Other Description | carbohydrate sulfotransferase 12|chondroitin 4-O-sulfotransferase 2|chondroitin 4-sulfotransferase 2|sulfotransferase Hlo |
Swissprots | Q9NXY7 Q9NRB3 A4D1Z9 Q502W3 |
Accessions | EAL23955 EAW87243 EAW87244 EAW87245 Q9NRB3 AF239822 AAF81692 AJ289131 CAB92133 AK223191 BAD96911 AK223211 BAD96931 AK313484 BAG36268 AY358574 AAQ88937 BC002918 AAH02918 BC015954 BC095492 AAH95492 DA078292 DA704587 DQ892969 ABM83895 DQ896217 ABM87216 XM_011515443 XP_011513745 XM_011515444 XP_011513746 NM_001243794 NP_001230723 NM_001243795 NP_001230724 NM_018641 NP_061111 |
Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung. {ECO:0000269|PubMed:10781601}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
C4ST-2 (D-20) - sc-68011 from Santa Cruz Biotechnology
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Anti-CHST12 antibody - ab68734 from Abcam
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Anti-CHST12 Antibody - LS-C307791 from LifeSpan Bioscience
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Anti-CHST12 Antibody (aa56-151) - LS-C307794 from LifeSpan Bioscience
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CHST12 Antibody - NBP1-91784 from Novus Biologicals
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CHST12 Antibody - H00055501-B01P from Novus Biologicals
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CHST12 Antibody (3D6) - H00055501-M01 from Novus Biologicals
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Anti-CHST12 antibody produced in rabbit - HPA041680 from Sigma-Aldrich
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Anti-CHST12 antibody produced in mouse - SAB1407666 from Sigma-Aldrich
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Monoclonal Anti-CHST12 antibody produced in mouse - SAB1403291 from Sigma-Aldrich
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CHST12-Antibody-N-term - AP21028b from Abgent, a WuXi AppTec company
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017) - 124985 from USBiological Life Science
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017) - 124986 from USBiological Life Science
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017)(AP) - 124986-AP from USBiological Life Science
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017)(Biotin) - 124986-Biotin from USBiological Life Science
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017)(FITC) - 124986-FITC from USBiological Life Science
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017)(HRP) - 124986-HRP from USBiological Life Science
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Anti -CHST12 (Carbohydrate Sulfotransferase 12, Chondroitin 4-O-sulfotransferase 2,Chondroitin 4-sulfotransferase 2, C4ST-2, C4ST2, Sulfotransferase Hlo, UNQ500/PRO1017)(PE) - 124986-PE from USBiological Life Science
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CHST12 antibody - 70R-16414 from Fitzgerald
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CarbohydRate (Chondroitin 4) Sulfotransferase 12 Antibody - abx111364 from Abbexa
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CHST12 antibody - 15341-1-AP from Acris Antibodies
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CHST12 antibody - H00055501-B01P from Acris Antibodies
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CHST12 antibody - H00055501-M01 from Acris Antibodies
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CHST12 antibody - 15341-1-AP from Proteintech Group
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CHST12, Polyclonal Antibody - MBS6008107 from MyBioSource
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