Gene Symbol | VAPB |
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Entrez Gene | 9217 |
Alt Symbol | ALS8, VAMP-B, VAP-B |
Species | Human |
Gene Type | protein-coding |
Description | VAMP (vesicle-associated membrane protein)-associated protein B and C |
Other Description | VAMP-associated 33 kDa protein|vesicle-associated membrane protein-associated protein B/C |
Swissprots | O95292 A2A2F2 Q9P0H0 O95293 |
Accessions | EAW75493 EAW75494 EAW75495 O95292 AB209665 BAD92902 AF086628 AAD13577 AF086629 AAD13578 AF160212 AAF67013 AK023241 BAG51174 AK024771 AK025720 AK123388 AK123538 BAG53909 AK124571 AK127252 BAC86901 AK128422 BAC87433 AK298036 BAG60336 AL833440 AY358464 AAQ88829 BC001712 AAH01712 BM968517 BT009811 AAP88813 DA450527 HQ447372 ADQ31858 NM_001195677 NP_001182606 NM_004738 NP_004729 NR_036633 |
Function | Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. {ECO:0000269|PubMed:16891305, ECO:0000269|PubMed:20940299, ECO:0000269|PubMed:22131369}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000269|PubMed:22131369}. |
Tissue Specificity | Ubiquitous. Isoform 1 predominates. |
Human VAPB full length protein - ab132025 from Abcam
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Human VAPB protein fragment - ab101214 from Abcam
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VAPB Antibody Blocking Peptide - LS-E6235 from LifeSpan Bioscience
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VAP-B Recombinant Protein - H00009217-P01 from Novus Biologicals
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VAP-B Partial Recombinant Protein - H00009217-Q02 from Novus Biologicals
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VAP-B Partial Recombinant Protein - H00009217-Q01 from Novus Biologicals
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Recombinant Human VAP-B Protein - NBP1-50886 from Novus Biologicals
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VAPB-Antibody-C-term-Blocking-Peptide - BP18906b from Abgent, a WuXi AppTec company
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Recombinant Human VAP-B, CF - 5855-VB-050 from R&D Systems
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VAPB Protein (OPPA02493) - OPPA02493 from Aviva Systems Biology
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Human ALS 8 protein - orb84520 from Biorbyt
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Human VAPB protein - orb169536 from Biorbyt
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VAPB protein (His tag) - 80R-1561 from Fitzgerald
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VAMP-associated protein B/C (VAPB) (1-222, His-tag) - AR09740PU-L from Acris Antibodies
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VAMP-associated protein B/C (VAPB) (1-222, His-tag) - AR09740PU-N from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-P01-10 from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-P01-25 from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-Q01-10 from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-Q01-25 from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-Q02 from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-Q02-10 from Acris Antibodies
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VAMP-associated protein B/C (VAPB) - H00009217-Q02-25 from Acris Antibodies
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VAPB, 1-222aa, Human, His tag, E.coli - 01-1776B from ARP American Research Products
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VAMP associated Recombinant Protein - 96-764 from ProSci
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VAPB fusion protein - Ag5857 from Proteintech Group
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