GNAL
| Gene Symbol | GNAL |
|---|---|
| Entrez Gene | 2774 |
| Alt Symbol | DYT25 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type |
| Other Description | adenylate cyclase-stimulating G alpha protein, olfactory type|guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide, olfactory type|guanine nucleotide-binding protein G(olf) subunit alpha |
| Swissprots | Q86XU3 B7ZA26 P38405 |
| Accessions | AAD00085 CAF32888 EAX01573 EAX01574 P38405 AF493893 AAM12607 AK090868 BAC03535 AK290054 BAF82743 AK295088 BAG58129 AK307260 AK313902 BAG36625 AK316141 BAH14512 BC050021 AAH50021 BP230966 BU163496 BX097239 CB241142 DA190390 DB475200 DC323877 DC336037 HQ448004 ADQ32485 L10665 AAC37535 XM_006722323 XP_006722386 XM_006722324 XP_006722387 XM_011525654 XP_011523956 NM_001142339 NP_001135811 NM_001261443 NP_001248372 NM_001261444 NP_001248373 NM_182978 NP_892023 NM_002071 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. |
| Tissue Specificity | Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined. |
| Top Pathways | Olfactory transduction, Calcium signaling pathway, Chagas disease (American trypanosomiasis), Amoebiasis, Dopaminergic synapse |
G α olf CRISPR/Cas9 KO Plasmid (h) - sc-401092 from Santa Cruz Biotechnology
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G α olf HDR Plasmid (h) - sc-401092-HDR from Santa Cruz Biotechnology
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G α olf Double Nickase Plasmid (h) - sc-401092-NIC from Santa Cruz Biotechnology
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G α olf Double Nickase Plasmid (h2) - sc-401092-NIC-2 from Santa Cruz Biotechnology
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G α olf CRISPR Activation Plasmid (h) - sc-401092-ACT from Santa Cruz Biotechnology
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G α olf CRISPR Activation Plasmid (h2) - sc-401092-ACT-2 from Santa Cruz Biotechnology
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G α olf Lentiviral Activation Particles (h) - sc-401092-LAC from Santa Cruz Biotechnology
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G α olf Lentiviral Activation Particles (h2) - sc-401092-LAC-2 from Santa Cruz Biotechnology
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G α olf siRNA (h) - sc-41754 from Santa Cruz Biotechnology
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G α olf shRNA Plasmid (h) - sc-41754-SH from Santa Cruz Biotechnology
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G α olf shRNA (h) Lentiviral Particles - sc-41754-V from Santa Cruz Biotechnology
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GNAL RNAi - H00002774-R02 from Novus Biologicals
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MISSION® esiRNA - EHU075151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9407 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9407 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06644 from Sigma-Aldrich
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GNAL siRNA (Human) - CRH1844 from Cohesion Biosciences
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GNAL RNAi - H00002774-R01 from Novus Biologicals
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GNAL - MBS8224593 from MyBioSource
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Human GNAL siRNA - orb262346 from Biorbyt
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GNAL shRNA Plasmid (Human) - CHH1844 from Cohesion Biosciences
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