DNASE1

Gene Symbol DNASE1
Entrez Gene 1773
Alt Symbol DNL1, DRNI
Species Human
Gene Type protein-coding
Description deoxyribonuclease I
Other Description DNase I, lysosomal|Dornase alfa|deoxyribonuclease-1|human urine deoxyribonuclease I
Swissprots B4DV35 Q14UU9 Q14UV0 P24855
Accessions AAC24721 AIQ84312 AIQ84313 AIQ84314 AIQ84315 AIQ84316 BAA11841 CCQ43307 EAW85343 EAW85344 P24855 AB188151 BAE96964 AB188152 BAE96965 AI378682 AJ298844 CAC12813 AK095412 AK126850 AK300914 BAG62547 BC015002 BC029437 AAH29437 BC064332 BC095475 BX648257 BX648480 DQ579705 DQ584015 DQ892098 ABM83024 DQ895291 ABM86217 M55983 AAA63170 XM_005255148 XP_005255205 XM_005255149 XP_005255206 XM_006720854 XP_006720917 XM_011522393 XP_011520695 XM_011522394 XP_011520696 XM_011522395 XP_011520697 XM_011522396 XP_011520698 XM_011522397 XP_011520699 XM_011522398 XP_011520700 XR_243264 XR_932790 NM_005223 NP_005214
Function Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). {ECO:0000250}.
Subcellular Location Secreted. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Tissue Specificity Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

DNase I (H-50) - sc-30058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DNase I (H-50): sc-30058. Western blot analysis of human recombinant DNase I. Kindly provided by Dr. David O' Hagan, Wayne State University School of Medicine and Karmanos Cancer Institute.

DNase I (L-19) - sc-19267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DNase I (L-19): sc-19267. Western blot analysis of DNase I expression in non-transfected: sc-117752 (A) and mouse DNase I transfected: sc-119807 (B) 293T whole cell lysates.

DNase I (L-18) - sc-31863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DNase I (L-18): sc-31863. Western blot analysis of DNase I expression in MCF7 whole cell lysate.

DNase I (B-4) - sc-376207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DNase l (B-4): sc-376207. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Anti-DNase I antibody - ab113241 from Abcam

Prices $385.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab113241, at 10 µg/ml, staining DNase I in Formalin-fixed, Paraffin-embedded Human Brain cerebellum tissue by Immunohistochemistry.

Anti-DNase I antibody - ab97393 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab97393 stained Caco-2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab97393, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-DNase I antibody - ab99117 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DNase I antibody (ab99117) at 1 µg/ml + PANC-1 cell lysate at 10 µg

Anti-DNase I antibody - ab167580 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DNase I antibody (ab167580) at 1 µg/mlLane 1 : DNase I transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-DNASE1 / DNase I Antibody IHC-plus™ - LS-B4846 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DNase I antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4846 concentration 10 ug/ml.

Anti-DNASE1 / DNase I Antibody - LS-C22774 from LifeSpan Bioscience

Prices $435.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody - LS-C48255 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody - LS-C59304 from LifeSpan Bioscience

Prices $395.00
Sizes 2 ml
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody - LS-C195846 from LifeSpan Bioscience

Prices $245.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody - LS-C147401 from LifeSpan Bioscience

Prices $455.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody - LS-C209228 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody (HRP) - LS-C209655 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody (Biotin) - LS-C209668 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody (aa71-120) - LS-C111110 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DNASE1 / DNase I antibody LS-C111110 Western blot of PANC1 cell lysate.

Anti-DNASE1 / DNase I Antibody (aa19-259, Biotin) - LS-C297962 from LifeSpan Bioscience

Prices $415.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-DNASE1 / DNase I Antibody (aa19-259, FITC) - LS-C302776 from LifeSpan Bioscience

Prices $445.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-DNASE1 / DNase I Antibody (aa19-259, FITC) - LS-C302777 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody (aa19-259, Biotin) - LS-C297961 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody (aa19-259) - LS-C292412 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant DNASE1 / DNase I.

Anti-DNASE1 / DNase I Antibody - LS-C341752 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNASE1 / DNase I Antibody - LS-C307288 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
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