| Gene Symbol | TNS2 |
|---|---|
| Entrez Gene | 23371 |
| Alt Symbol | C1-TEN, C1TEN, TENC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tensin 2 |
| Other Description | C1 domain-containing phosphatase and tensin homolog|tensin like C1 domain containing phosphatase (tensin 2)|tensin like C1 domain-containing phosphatase|tensin-2|tensin-like C1 domain-containing phosphatase |
| Swissprots | A2VDI8 Q7Z5T9 A2VDF2 Q9UPS7 Q8NFG0 Q9NT29 Q8NFF9 Q76MW6 A2VDF3 A5PKY4 Q96P25 Q63HR2 Q2NL80 |
| Accessions | EAW96658 EAW96659 EAW96660 Q63HR2 AB028998 BAA83027 AF417490 AAL14641 AF518728 AAN03866 AF518729 AAM74225 AK131320 BAG54765 AK172747 BAD18734 AL137564 CAB70815 BC054099 AAH54099 BC110854 AAI10855 BC129828 AAI29829 BC129829 AAI29830 BC131503 AAI31504 BC142668 AAI42669 BC142712 AAI42713 BC150259 AAI50260 BX647126 CAH56176 CA306931 CR936725 XM_006719302 XP_006719365 XM_006719303 XP_006719366 XM_006719304 XP_006719367 XM_011538079 XP_011536381 NM_015319 NP_056134 NM_170754 NP_736610 NM_198316 NP_938072 |
| Function | Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. {ECO:0000269|PubMed:15817639}. |
| Subcellular Location | Cell junction, focal adhesion {ECO:0000269|PubMed:11792844}. Cell membrane {ECO:0000269|PubMed:11792844}; Peripheral membrane protein {ECO:0000269|PubMed:11792844}; Cytoplasmic side {ECO:0000269|PubMed:11792844}. Note=Detected at the end of actin stress fibers. |
| Tissue Specificity | Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine. {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:12470648}. |
Tns2 CRISPR/Cas9 KO Plasmid (h) - sc-411726 from Santa Cruz Biotechnology
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Tns2 HDR Plasmid (h) - sc-411726-HDR from Santa Cruz Biotechnology
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Tns2 Double Nickase Plasmid (h) - sc-411726-NIC from Santa Cruz Biotechnology
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Tns2 Double Nickase Plasmid (h2) - sc-411726-NIC-2 from Santa Cruz Biotechnology
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Tns2 CRISPR Activation Plasmid (h) - sc-411726-ACT from Santa Cruz Biotechnology
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Tns2 CRISPR Activation Plasmid (h2) - sc-411726-ACT-2 from Santa Cruz Biotechnology
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Tns2 Lentiviral Activation Particles (h) - sc-411726-LAC from Santa Cruz Biotechnology
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Tns2 Lentiviral Activation Particles (h2) - sc-411726-LAC-2 from Santa Cruz Biotechnology
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Tns2 siRNA (h) - sc-96197 from Santa Cruz Biotechnology
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Tns2 shRNA Plasmid (h) - sc-96197-SH from Santa Cruz Biotechnology
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Tns2 shRNA (h) Lentiviral Particles - sc-96197-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU156791 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0887 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0886 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0888 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21214 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21214 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04090 from Sigma-Aldrich
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TENC1 siRNA (Human) - CRH8219 from Cohesion Biosciences
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TENC1 - MBS8214388 from MyBioSource
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shRNA set against Human TENC1 (NM_198316.1) - SHH425672 from Creative biogene
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shRNA set against Human TENC1(NM_170754.2) - SHL064866 from Creative biogene
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shRNA set against Human TENC1(NM_015319.2) - SHL064902 from Creative biogene
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shRNA set against Human TENC1(NM_198316.1) - SHL064944 from Creative biogene
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Human TENC1 siRNA - orb268721 from Biorbyt
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