Gene Symbol | SOAT2 |
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Entrez Gene | 8435 |
Alt Symbol | ACACT2, ACAT2, ARGP2 |
Species | Human |
Gene Type | protein-coding |
Description | sterol O-acyltransferase 2 |
Other Description | ACAT-2|acyl Co-A: cholesterol acyltransferase 2|acyl coenzyme A:cholesterol acyltransferase 2|acyl-CoA:cholesterol acyltransferase 2|acyl-coenzyme A:cholesterol acyltransferase 2|cholesterol acyltransferase 2 |
Swissprots | F5H7W4 O75908 Q4VBA1 Q9UNR2 Q96TD4 I6L9H9 Q4VB99 |
Accessions | AAK18275 AAK48829 EAW96665 O75908 AF059203 AAC63998 AF099031 AAC78335 BC096090 AAH96090 BC096091 AAH96091 BC096092 AAH96092 BC099626 AAH99626 XM_011538849 XP_011537151 XM_011538850 XP_011537152 XM_011538851 XP_011537153 XR_944775 XR_944777 XR_944778 NM_003578 NP_003569 |
Function | Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Tissue Specificity | Expression seems confined in hepatocytes and enterocytes. {ECO:0000269|PubMed:16331323}. |
Top Pathways | Steroid biosynthesis |
SOAT2 CRISPR/Cas9 KO Plasmid (h) - sc-409713 from Santa Cruz Biotechnology
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SOAT2 HDR Plasmid (h) - sc-409713-HDR from Santa Cruz Biotechnology
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SOAT2 Double Nickase Plasmid (h) - sc-409713-NIC from Santa Cruz Biotechnology
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SOAT2 Double Nickase Plasmid (h2) - sc-409713-NIC-2 from Santa Cruz Biotechnology
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SOAT2 CRISPR Activation Plasmid (h) - sc-409713-ACT from Santa Cruz Biotechnology
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SOAT2 CRISPR Activation Plasmid (h2) - sc-409713-ACT-2 from Santa Cruz Biotechnology
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SOAT2 Lentiviral Activation Particles (h) - sc-409713-LAC from Santa Cruz Biotechnology
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SOAT2 Lentiviral Activation Particles (h2) - sc-409713-LAC-2 from Santa Cruz Biotechnology
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SOAT2 siRNA (h) - sc-76535 from Santa Cruz Biotechnology
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SOAT2 shRNA Plasmid (h) - sc-76535-SH from Santa Cruz Biotechnology
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SOAT2 shRNA (h) Lentiviral Particles - sc-76535-V from Santa Cruz Biotechnology
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ACAT2 RNAi - H00000039-R01 from Novus Biologicals
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MISSION® esiRNA - EHU160971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20318 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20318 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03489 from Sigma-Aldrich
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SOAT2 siRNA (Human) - CRH5525 from Cohesion Biosciences
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SOAT2 - MBS8203231 from MyBioSource
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shRNA set against Human SOAT2 (NM_003578.3) - SHH414916 from Creative biogene
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shRNA set against Human SOAT2(NM_003578.3) - SHG028393 from Creative biogene
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SOAT2 shRNA Plasmid (Human) - CHH5525 from Cohesion Biosciences
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SOAT2 miRNA 3'UTR clone - MiUTR1H-09728 from Creative biogene
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