Gene Symbol | TAF1B |
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Entrez Gene | 9014 |
Alt Symbol | MGC:9349, RAF1B, RAFI63, SL1, TAFI63 |
Species | Human |
Gene Type | protein-coding |
Description | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa |
Other Description | RNA polymerase I-specific TBP-associated factor 63 kDa|SL1, 63kD subunit|TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD|TATA box-binding protein-associated factor 1B|TATA box-binding protein-associated factor RNA polymerase I subunit B|TBP-associated factor 1B|transcription initiation factor SL1/TIF-IB subunit B |
Swissprots | F8WD72 Q53T94 Q8WVC3 Q15574 B4DI42 |
Accessions | AAX93272 EAX00974 EAX00975 EAX00976 Q53T94 AA746267 AK026521 AK295402 BAG58354 AK308070 AK309751 AK315098 BC018137 AAH18137 CA423871 DA910748 DQ894659 ABM85585 L39061 AAA62863 XM_011510410 XP_011508712 XM_011510411 XP_011508713 XM_011510412 XP_011508714 XM_011510413 XP_011508715 NM_005680 NP_005671 |
Function | Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198, ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500, ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}. |
Subcellular Location | Nucleus, nucleolus. |
TAF I p63 CRISPR/Cas9 KO Plasmid (h) - sc-404427 from Santa Cruz Biotechnology
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TAF I p63 HDR Plasmid (h) - sc-404427-HDR from Santa Cruz Biotechnology
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TAF I p63 Double Nickase Plasmid (h) - sc-404427-NIC from Santa Cruz Biotechnology
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TAF I p63 Double Nickase Plasmid (h2) - sc-404427-NIC-2 from Santa Cruz Biotechnology
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TAF I p63 CRISPR Activation Plasmid (h) - sc-404427-ACT from Santa Cruz Biotechnology
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TAF I p63 CRISPR Activation Plasmid (h2) - sc-404427-ACT-2 from Santa Cruz Biotechnology
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TAF I p63 Lentiviral Activation Particles (h) - sc-404427-LAC from Santa Cruz Biotechnology
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TAF I p63 Lentiviral Activation Particles (h2) - sc-404427-LAC-2 from Santa Cruz Biotechnology
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TAF1B RNAi - H00009014-R01 from Novus Biologicals
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MISSION® esiRNA - EHU158171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20966 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20966 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03296 from Sigma-Aldrich
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TAF1B siRNA (Human) - CRH5943 from Cohesion Biosciences
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TAF1B - MBS8208851 from MyBioSource
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TAF I p63 siRNA (h) - sc-38488 from Santa Cruz Biotechnology
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TAF I p63 shRNA Plasmid (h) - sc-38488-SH from Santa Cruz Biotechnology
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TAF I p63 shRNA (h) Lentiviral Particles - sc-38488-V from Santa Cruz Biotechnology
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shRNA set against Human TAF1B (NM_005680.2) - SHH422648 from Creative biogene
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Human TAF1B siRNA - orb266445 from Biorbyt
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TAF1B shRNA Plasmid (Human) - CHH5943 from Cohesion Biosciences
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TAF1B miRNA 3'UTR clone - MiUTR3H-07190 from Creative biogene
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