LINGO1

Gene Symbol LINGO1
Entrez Gene 84894
Alt Symbol LERN1, LRRN6A, UNQ201
Species Human
Gene Type protein-coding
Description leucine rich repeat and Ig domain containing 1
Other Description leucine rich repeat neuronal 6A|leucine-rich repeat and immunoglobulin domain-containing protein 1|leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1|leucine-rich repeat neuronal protein 1
Swissprots Q8N3K5 D3DW80 Q6VVG2 Q6UXM3 Q6VVG0 Q6NUK3 Q96K52 Q6VVG1 Q96FE5
Accessions EAW99195 EAW99196 EAW99197 EAW99198 Q96FE5 AK027500 BAB55157 AK291363 BAF84052 AL109677 AL834260 CAD38935 AY324320 AAQ97216 AY324322 AAQ97217 AY324323 AAQ97218 AY358284 AAQ88651 BC011057 AAH11057 BC068558 AAH68558 BI523562 BI669707 BI825536 BX355455 DA150164 DA182630 DA183673 DA232085 DA328735 DA410114 DA483616 DA494936 DA525603 DA787289 DB165168 H11343 HY342106 XM_011522117 XP_011520419 XM_011522118 XP_011520420 NM_001301186 NP_001288115 NM_001301187 NP_001288116 NM_001301189 NP_001288118 NM_001301191 NP_001288120 NM_001301192 NP_001288121 NM_001301194 NP_001288123 NM_001301195 NP_001288124 NM_001301197 NP_001288126 NM_001301198 NP_001288127 NM_001301199 NP_001288128 NM_001301200 NP_001288129 NM_032808 NP_116197
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. {ECO:0000269|PubMed:14686891, ECO:0000269|PubMed:15895088, ECO:0000269|PubMed:17726113}.

Lingo-1 (C-15) - sc-48582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Lingo-1 (H-65) - sc-134597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Lingo-1 (N-12) - sc-48584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Lingo-1 (K-13) - sc-48583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Lingo-1 (N-18) - sc-48585 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Lingo-1 (F-22) - sc-130803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Lingo-1 (F-22): sc-130803. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human brain tissue showing cytoplasmic localization.

Anti-Lingo1 antibody - ab101810 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Lingo1 antibody - ab103098 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Lingo1 antibody (ab103098) at 1/100 dilution + Mouse cerebellum tissue lysate at 35 µg

Anti-LINGO1 Antibody (N-Terminus, AP) - LS-C278894 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (aa57-85, PE) - LS-C261963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (N-Terminus, APC) - LS-C278895 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (N-Terminus, FITC) - LS-C278897 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (N-Terminus, Biotin) - LS-C278896 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (N-Terminus, PE) - LS-C278901 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (N-Terminus, Azide-free, HRP) - LS-C278898 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (phospho-Ser596) - LS-C322671 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (aa64-93) - LS-C322673 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (aa583-613) - LS-C322674 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (N-Terminus) - LS-C327754 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (aa57-85) - LS-C165788 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of LINGO1 Antibody in mouse cerebellum tissue lysates (35 ug/lane). LINGO1 (arrow) was detected using the purified antibody.

Anti-LINGO1 Antibody - LS-C155580 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE LINGO1 antibody diluted at 1:2000

Anti-LINGO1 Antibody (aa575-603) - LS-C165787 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LINGO-1(LRRN6A)-S596 Antibody IHC of formalin-fixed and paraffin-embedded brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the LINGO-1(LRRN6A)-S596 Antibody for immunohistochemistry.

Anti-LINGO1 Antibody (aa62-92) - LS-C100860 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-LINGO1 Antibody (aa575-603, AP) - LS-C261943 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LINGO1 Antibody (aa575-603, APC) - LS-C261944 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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