Crhr1

Gene Symbol Crhr1
Entrez Gene 12921
Alt Symbol CRFR1, Crhr
Species Mouse
Gene Type protein-coding
Description corticotropin releasing hormone receptor 1
Other Description CRF 1 receptor|CRF-R-1|CRF-R1|CRF-R1alpha|CRFR-1|CRH receptor subtype-1 isoform-3|CRH-R-1|CRH-R1|corticotropin-releasing factor receptor 1|corticotropin-releasing hormone receptor 1
Swissprots P35347
Accessions EDL34208 P35347 AB375515 BAG55670 AF369654 AAL46634 AF369655 AF369656 AAL46635 AF483484 AAL90758 AF483485 AAL90759 AK144430 AK158806 BAE34674 BC103675 AAI03676 BC104735 AAI04736 BC105673 AAI05674 BC105675 AAI05676 FJ668671 ACV89823 X72305 CAA51053 XM_006532123 XP_006532186 NM_007762 NP_031788
Function G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:8243652, ECO:0000269|PubMed:9655498}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:8243652}; Multi-pass membrane protein {ECO:0000269|PubMed:8243652}. Endosome {ECO:0000250}. Note=Agonist-binding promotes endocytosis. {ECO:0000250}.
Tissue Specificity Detected in brain cortex (at protein level). {ECO:0000269|PubMed:23576434}.
Top Pathways Long-term depression, Neuroactive ligand-receptor interaction

Corticotropin-releasing factor receptor 1 (Crhr1), Recombinant Protein - MBS965901 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Corticotropin-releasing factor receptor 1 (Crhr1), Recombinant Protein - MBS7013047 from MyBioSource

Category Protein
Prices $1,200.00, $2,185.00, $3,390.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Mouse
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