Gene Symbol | Crhr1 |
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Entrez Gene | 12921 |
Alt Symbol | CRFR1, Crhr |
Species | Mouse |
Gene Type | protein-coding |
Description | corticotropin releasing hormone receptor 1 |
Other Description | CRF 1 receptor|CRF-R-1|CRF-R1|CRF-R1alpha|CRFR-1|CRH receptor subtype-1 isoform-3|CRH-R-1|CRH-R1|corticotropin-releasing factor receptor 1|corticotropin-releasing hormone receptor 1 |
Swissprots | P35347 |
Accessions | EDL34208 P35347 AB375515 BAG55670 AF369654 AAL46634 AF369655 AF369656 AAL46635 AF483484 AAL90758 AF483485 AAL90759 AK144430 AK158806 BAE34674 BC103675 AAI03676 BC104735 AAI04736 BC105673 AAI05674 BC105675 AAI05676 FJ668671 ACV89823 X72305 CAA51053 XM_006532123 XP_006532186 NM_007762 NP_031788 |
Function | G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:8243652, ECO:0000269|PubMed:9655498}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:8243652}; Multi-pass membrane protein {ECO:0000269|PubMed:8243652}. Endosome {ECO:0000250}. Note=Agonist-binding promotes endocytosis. {ECO:0000250}. |
Tissue Specificity | Detected in brain cortex (at protein level). {ECO:0000269|PubMed:23576434}. |
Top Pathways | Long-term depression, Neuroactive ligand-receptor interaction |
CRF-RI CRISPR/Cas9 KO Plasmid (m) - sc-419802 from Santa Cruz Biotechnology
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CRF-RI HDR Plasmid (m) - sc-419802-HDR from Santa Cruz Biotechnology
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CRF-RI Double Nickase Plasmid (m) - sc-419802-NIC from Santa Cruz Biotechnology
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CRF-RI Double Nickase Plasmid (m2) - sc-419802-NIC-2 from Santa Cruz Biotechnology
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CRF-RI CRISPR Activation Plasmid (m) - sc-419802-ACT from Santa Cruz Biotechnology
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CRF-RI CRISPR Activation Plasmid (m2) - sc-419802-ACT-2 from Santa Cruz Biotechnology
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CRF-RI Lentiviral Activation Particles (m) - sc-419802-LAC from Santa Cruz Biotechnology
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CRF-RI Lentiviral Activation Particles (m2) - sc-419802-LAC-2 from Santa Cruz Biotechnology
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CRF-RI siRNA (m) - sc-39915 from Santa Cruz Biotechnology
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CRF-RI shRNA Plasmid (m) - sc-39915-SH from Santa Cruz Biotechnology
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CRF-RI shRNA (m) Lentiviral Particles - sc-39915-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU075341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN29221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29221 from Sigma-Aldrich
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CRHR1 siRNA (Mouse) - CRM0834 from Cohesion Biosciences
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CRHR1 - MBS8211161 from MyBioSource
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shRNA set against Mouse CRHR1 (NM_007762.4) - SHH269493 from Creative biogene
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shRNA set against Mouse Crhr1(NM_007762.4) - SHG199405 from Creative biogene
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CRHR1 shRNA Plasmid (Mouse) - CHM0834 from Cohesion Biosciences
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CRHR1 miRNA 3'UTR clone - MiUTR1M-03324 from Creative biogene
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