PALM
| Gene Symbol | PALM |
|---|---|
| Entrez Gene | 5064 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | paralemmin |
| Other Description | paralemmin-1 |
| Swissprots | Q9UPJ4 Q9UQS2 Q92559 O43359 O95673 O75781 Q9UQS3 |
| Accessions | AAC62429 CAA76151 EAW61161 EAW61162 EAW61163 EAW61164 O75781 AK022919 BAG51135 AK299809 BAH13135 AK301181 BAH13424 AK315168 BAG37611 BC019596 BC032449 AAH32449 BM667870 BP199809 BU508077 CN344023 D87460 BAA13400 DA521203 HQ447328 ADQ31814 Y14770 CAB37400 Y16278 CAA76152 XM_005259565 XP_005259622 XM_005259566 XP_005259623 XM_011528043 XP_011526345 XM_011528044 XP_011526346 NM_001040134 NP_001035224 NM_002579 NP_002570 |
| Function | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. |
| Tissue Specificity | Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland. |
Paralemmin CRISPR/Cas9 KO Plasmid (h) - sc-409660 from Santa Cruz Biotechnology
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Paralemmin HDR Plasmid (h) - sc-409660-HDR from Santa Cruz Biotechnology
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Paralemmin Double Nickase Plasmid (h) - sc-409660-NIC from Santa Cruz Biotechnology
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Paralemmin Double Nickase Plasmid (h2) - sc-409660-NIC-2 from Santa Cruz Biotechnology
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Paralemmin CRISPR Activation Plasmid (h) - sc-409660-ACT from Santa Cruz Biotechnology
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Paralemmin CRISPR Activation Plasmid (h2) - sc-409660-ACT-2 from Santa Cruz Biotechnology
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Paralemmin Lentiviral Activation Particles (h) - sc-409660-LAC from Santa Cruz Biotechnology
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Paralemmin Lentiviral Activation Particles (h2) - sc-409660-LAC-2 from Santa Cruz Biotechnology
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Paralemmin siRNA (h) - sc-62753 from Santa Cruz Biotechnology
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Paralemmin shRNA Plasmid (h) - sc-62753-SH from Santa Cruz Biotechnology
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Paralemmin shRNA (h) Lentiviral Particles - sc-62753-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16293 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16293 from Sigma-Aldrich
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PALM siRNA (Human) - CRH3365 from Cohesion Biosciences
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Paralemmin RNAi - H00005064-R02 from Novus Biologicals
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Paralemmin RNAi - H00005064-R01 from Novus Biologicals
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shRNA set against Human PALM (NM_002579.2) - SHH370248 from Creative biogene
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shRNA set against Human PALM(NM_001040134.1) - SHR086278 from Creative biogene
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shRNA set against Human PALM(NM_002579.2) - SHR086314 from Creative biogene
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PALM shRNA Plasmid (Human) - CHH3365 from Cohesion Biosciences
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PALM miRNA 3'UTR clone - MiUTR1H-07483 from Creative biogene
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PALM miRNA 3'UTR clone - MiUTR1H-07484 from Creative biogene
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