Gene Symbol | FOXH1 |
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Entrez Gene | 8928 |
Alt Symbol | FAST-1, FAST1 |
Species | Human |
Gene Type | protein-coding |
Description | forkhead box H1 |
Other Description | TGF-beta/activin signal transducer|fast-2|forkhead activin signal transducer 2|forkhead activin signal transducer-1|forkhead box protein H1|hFAST-1 |
Swissprots | D3DWM4 O75593 |
Accessions | EAW82083 EAW82084 O75593 AF076292 AAC34303 BC051376 BC065377 AAH65377 BC111604 AAI11605 BE550635 CX782591 NM_003923 NP_003914 |
Function | Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269|PubMed:9702198}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9702198}. |
FAST-1 CRISPR/Cas9 KO Plasmid (h) - sc-406686 from Santa Cruz Biotechnology
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FAST-1 HDR Plasmid (h) - sc-406686-HDR from Santa Cruz Biotechnology
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FAST-1 Double Nickase Plasmid (h) - sc-406686-NIC from Santa Cruz Biotechnology
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FAST-1 Double Nickase Plasmid (h2) - sc-406686-NIC-2 from Santa Cruz Biotechnology
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FAST-1 CRISPR Activation Plasmid (h) - sc-406686-ACT from Santa Cruz Biotechnology
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FAST-1 CRISPR Activation Plasmid (h2) - sc-406686-ACT-2 from Santa Cruz Biotechnology
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FAST-1 Lentiviral Activation Particles (h) - sc-406686-LAC from Santa Cruz Biotechnology
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FAST-1 Lentiviral Activation Particles (h2) - sc-406686-LAC-2 from Santa Cruz Biotechnology
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FAST-1/2 siRNA (h) - sc-35364 from Santa Cruz Biotechnology
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FAST-1/2 shRNA Plasmid (h) - sc-35364-SH from Santa Cruz Biotechnology
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FAST-1/2 shRNA (h) Lentiviral Particles - sc-35364-V from Santa Cruz Biotechnology
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FoxH1 RNAi - H00008928-R01 from Novus Biologicals
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MISSION® esiRNA - EHU150471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8896 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8896 from Sigma-Aldrich
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FOXH1 siRNA (Human) - CRH5903 from Cohesion Biosciences
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FOXH1 - MBS8215110 from MyBioSource
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FAST-1 CRISPR/Cas9 KO Plasmid (h2) - sc-406686-KO-2 from Santa Cruz Biotechnology
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FAST-1 HDR Plasmid (h2) - sc-406686-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Foxh1 (NM_003923.2) - SHH296569 from Creative biogene
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Human FOXH1 siRNA - orb266405 from Biorbyt
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FOXH1 shRNA Plasmid (Human) - CHH5903 from Cohesion Biosciences
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