FAS

Gene Symbol	FAS
Entrez Gene	355
Alt Symbol	ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Species	Human
Gene Type	protein-coding
Description	Fas cell surface death receptor
Other Description	APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, member 6
Swissprots	Q5T9P2 Q14295 P25445 Q6SSE9 Q5T9P3 Q14294 B6VNV4 A9UJX4 Q16652 Q14292 Q5T9P1 Q14293
Accessions	AAC16236 AAC16237 AAR08906 AGR88646 AGR88647 AGR88648 BAA20850 CAC35539 CAC35540 CAC35541 CAD48928 CAD48929 CAD48930 CAD48931 CAD48932 EAW50147 EAW50148 EAW50149 EAW50150 EAW50151 EAW50152 P25445 AB209361 BAD92598 AK026195 AK290978 BAF83667 AK311164 AK311424 AK311499 AY495076 AAS76663 BC012479 AAH12479 BC065736 CR450307 CAG29303 DA759225 DB284727 DQ894675 ABM85601 EU481974 ACC91884 FJ200481 ACO54878 FJ373045 ACP28876 FJ373046 ACP28877 FM246457 FM246458 CAR92543 FM246459 CAR92544 HG503127 M67454 AAA63174 S78781 AAD14292 X63717 CAA45250 X83490 X83491 X83492 X83493 X89101 CAA61473 Z47993 CAA88031 Z47994 CAA88032 Z47995 CAA88033 Z66556 Z70519 CAA94430 Z70520 CAA94431 XM_006717819 XP_006717882 XM_011539764 XP_011538066 XM_011539765 XP_011538067 XM_011539766 XP_011538068 XM_011539767 XP_011538069 XR_945732 XR_945733 NM_000043 NP_000034 NM_152871 NP_690610 NM_152872 NP_690611 NR_028033 NR_028034 NR_028035 NR_028036 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.
Subcellular Location	Isoform 5: Secreted.
Tissue Specificity	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. {ECO:0000269|PubMed:7575433}.
Top Pathways	Proteoglycans in cancer, Herpes simplex infection, TNF signaling pathway, Influenza A, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FAS 293T Cell Transient Overexpression Lysate(Denatured) - H00000355-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

FAS overexpression lysate - LY407241 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FAS overexpression lysate - LY424961 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FAS 293 Cell Lysate - 410343 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Fas/TNFRSF6/CD95 Overexpression Lysate (Denatured) - H00000355-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Fas/TNFRSF6/CD95 Overexpression Lysate (Native) - NBL1-10599 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Fas/TNFRSF6/CD95 Overexpression Lysate (Native) - NBL1-10598 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FAS (h): 293T Lysate - sc-113770 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

FAS Over-expression Lysate Product - GWB-FA34B0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

FAS Over-expression Lysate Product - GWB-586DE6 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human FAS / CD95 / APO-1 / TNFRSF6 HEK293 Cell Lysate (WB positive control) - 10217-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Cynomolgus FAS / CD95 / APO-1 / TNFRSF6 HEK293 Cell Lysate (WB positive control) - 90273-CCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus FAS / CD95 / APO-1 / TNFRSF6 HEK293 Cell Lysate (WB positive control) - 90273-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human FAS / CD95 / APO-1 / TNFRSF6 HEK293 Cell Lysate (WB positive control) - 10217-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human FAS Human Cells Transfected Lysate (positive control) (denatured) - orb232808 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human CD95 Human Cells Transfected Lysate (positive control) (denatured) - orb173565 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human FAS Knockdown Stable Cell Line - CSC-DC005538 from Creative biogene Category Cell Line Species Human

FAS Knockout Cell Line-HeLa - CSC-RT1790 from Creative biogene Category Cell Line Species Human

FAS KO Cell Lysate-HeLa - CLKO-1639 from Creative biogene Category Cell Lysate

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