FAS

Gene Symbol	FAS
Entrez Gene	355
Alt Symbol	ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Species	Human
Gene Type	protein-coding
Description	Fas cell surface death receptor
Other Description	APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, member 6
Swissprots	Q5T9P2 Q14295 P25445 Q6SSE9 Q5T9P3 Q14294 B6VNV4 A9UJX4 Q16652 Q14292 Q5T9P1 Q14293
Accessions	AAC16236 AAC16237 AAR08906 AGR88646 AGR88647 AGR88648 BAA20850 CAC35539 CAC35540 CAC35541 CAD48928 CAD48929 CAD48930 CAD48931 CAD48932 EAW50147 EAW50148 EAW50149 EAW50150 EAW50151 EAW50152 P25445 AB209361 BAD92598 AK026195 AK290978 BAF83667 AK311164 AK311424 AK311499 AY495076 AAS76663 BC012479 AAH12479 BC065736 CR450307 CAG29303 DA759225 DB284727 DQ894675 ABM85601 EU481974 ACC91884 FJ200481 ACO54878 FJ373045 ACP28876 FJ373046 ACP28877 FM246457 FM246458 CAR92543 FM246459 CAR92544 HG503127 M67454 AAA63174 S78781 AAD14292 X63717 CAA45250 X83490 X83491 X83492 X83493 X89101 CAA61473 Z47993 CAA88031 Z47994 CAA88032 Z47995 CAA88033 Z66556 Z70519 CAA94430 Z70520 CAA94431 XM_006717819 XP_006717882 XM_011539764 XP_011538066 XM_011539765 XP_011538067 XM_011539766 XP_011538068 XM_011539767 XP_011538069 XR_945732 XR_945733 NM_000043 NP_000034 NM_152871 NP_690610 NM_152872 NP_690611 NR_028033 NR_028034 NR_028035 NR_028036 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.
Subcellular Location	Isoform 5: Secreted.
Tissue Specificity	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. {ECO:0000269|PubMed:7575433}.
Top Pathways	Proteoglycans in cancer, Herpes simplex infection, TNF signaling pathway, Influenza A, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Fas protein fragment - ab155635 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human Fas protein fragment - ab155701 from Abcam Category Protein Prices $352.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human Fas protein fragment - ab199806 from Abcam Category Protein Prices $107.00 Sizes 5 µg Source E. coli Species Human

Fas peptide - ab2438 from Abcam Category Peptide

Human Fas full length protein - ab131871 from Abcam Category Protein Source Wheat germ Species Human

Human Fas protein fragment - ab50092 from Abcam Category Protein Source E. coli Species Human

Human Fas protein fragment - ab117157 from Abcam Category Protein Source E. coli Species Human

CD95 / FAS Antibody Blocking Peptide - LS-E10658 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD95 / FAS Antibody Blocking Peptide - LS-E27169 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD95 / FAS Antibody Blocking Peptide - LS-E7340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD95 / FAS Antibody Blocking Peptide - LS-E21622 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD95 / FAS Antibody Blocking Peptide - LS-E9625 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Fas/TNFRSF6/CD95 Partial Recombinant Protein - H00000355-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Fas/TNFRSF6/CD95 Recombinant Protein - H00000355-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Fas/TNFRSF6/CD95 Protein - NBP1-94195 from Novus Biologicals Category Protein Prices $499.00 Sizes 500 µg Species Human

Fas/TNFRSF6/CD95 Recombinant Protein - H00000355-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Fas/TNFRSF6/CD95 Peptide - P1463 from Novus Biologicals Category Peptide Species Human

FAS-Antibody-Center-Y232-Blocking-peptide - BP12628c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FAS-Antibody-C-term-Y291-Blocking-peptide - BP12467b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-FASY291-Antibody-Blocking-peptide - BP3310a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

FAS-Antibody-Center-Blocking-Peptide - BP8530c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Fas Recombinant Protein (active) - GTX48226-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

Fas blocking peptide - GTX88349-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Fas peptide - GTX22438 from GeneTex Category Peptide Prices $179.00 Sizes 500 μl Species Human

Recombinant Human Fas/TNFRSF6 Fc Chimera - 326-FS-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

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