Gene Symbol | DMRT2 |
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Entrez Gene | 10655 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | doublesex and mab-3 related transcription factor 2 |
Other Description | DSXL-2|doublesex- and mab-3-related transcription factor 2|doublesex-like 2 protein|terra-like protein |
Swissprots | Q9NQR6 Q9NPG6 B9EGJ1 B1ANC0 Q9Y5R5 |
Accessions | EAW58816 EAW58817 EAW58818 Q9Y5R5 AA771859 AF130729 AAD40475 AF284221 AAF86289 AF284222 AAF86290 AF284223 AAF86291 AF284224 AAF86293 AF284225 AAF86295 AK290794 BAF83483 BC030204 AAH30204 BC136493 AAI36494 BP274385 BX107686 BX647565 CAI46061 Y19052 CAB59891 XM_006716717 XP_006716780 XM_006716718 XP_006716781 XM_011517687 XP_011515989 XM_011517689 XP_011515991 XM_011517690 XP_011515992 XM_011517691 XP_011515993 XM_011517692 XP_011515994 XM_011517693 XP_011515995 XM_011517694 XP_011515996 XM_011517695 XP_011515997 XM_011517696 XP_011515998 NM_001130865 NP_001124337 NM_006557 NP_006548 NM_181872 NP_870987 |
Function | Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070}. |
Tissue Specificity | Expressed in testis, kidney and skeletal muscle. |
DMRT2 CRISPR/Cas9 KO Plasmid (h) - sc-408189 from Santa Cruz Biotechnology
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DMRT2 HDR Plasmid (h) - sc-408189-HDR from Santa Cruz Biotechnology
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DMRT2 Double Nickase Plasmid (h) - sc-408189-NIC from Santa Cruz Biotechnology
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DMRT2 Double Nickase Plasmid (h2) - sc-408189-NIC-2 from Santa Cruz Biotechnology
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DMRT2 CRISPR Activation Plasmid (h) - sc-408189-ACT from Santa Cruz Biotechnology
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DMRT2 CRISPR Activation Plasmid (h2) - sc-408189-ACT-2 from Santa Cruz Biotechnology
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DMRT2 Lentiviral Activation Particles (h) - sc-408189-LAC from Santa Cruz Biotechnology
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DMRT2 Lentiviral Activation Particles (h2) - sc-408189-LAC-2 from Santa Cruz Biotechnology
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DMRT2 siRNA (h) - sc-77157 from Santa Cruz Biotechnology
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DMRT2 shRNA Plasmid (h) - sc-77157-SH from Santa Cruz Biotechnology
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DMRT2 shRNA (h) Lentiviral Particles - sc-77157-V from Santa Cruz Biotechnology
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DMRT2 RNAi - H00010655-R02 from Novus Biologicals
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DMRT2 RNAi - H00010655-R01 from Novus Biologicals
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MISSION® esiRNA - EHU123731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7314 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7314 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10454 from Sigma-Aldrich
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DMRT2 siRNA (Human) - CRH7263 from Cohesion Biosciences
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DMRT2 - MBS8230067 from MyBioSource
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shRNA set against Human DMRT2 (NM_181872.4) - SHH278869 from Creative biogene
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Human DMRT2 siRNA - orb267765 from Biorbyt
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DMRT2 shRNA Plasmid (Human) - CHH7263 from Cohesion Biosciences
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DMRT2 miRNA 3'UTR clone - MiUTR4H-TG11074 from Creative biogene
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