| Gene Symbol |
MACROD2
|
| Entrez Gene |
140733
|
| Alt Symbol |
C20orf133
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MACRO domain containing 2
|
| Other Description |
MACRO domain-containing protein 2|O-acetyl-ADP-ribose deacetylase MACROD2|[Protein ADP-ribosylglutamate] hydrolase
|
| Swissprots |
Q5W199 A1Z1Q3 B0QZ39 A6NFF7 Q495E0 Q6ZN71 Q0P6D5 B3KWV0
|
| Accessions |
A1Z1Q3 EAX10302 AK125899 BAG54262 AK131348 BAD18504 BC018687 AAH18687 BC035876 BC036403 BC101216 BC101217 BC101218 BC101219 BC126936 BC128036 BX281637 DB125529 DB495787 DR001087 EF159161 ABM46908 XM_011529168 XP_011527470 XM_011529169 XP_011527471 NM_001033087 NP_001028259 NM_080676 NP_542407
|
| Function |
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}.
|
| Subcellular Location |
Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
|