Gene Symbol | MACROD2 |
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Entrez Gene | 140733 |
Alt Symbol | C20orf133 |
Species | Human |
Gene Type | protein-coding |
Description | MACRO domain containing 2 |
Other Description | MACRO domain-containing protein 2|O-acetyl-ADP-ribose deacetylase MACROD2|[Protein ADP-ribosylglutamate] hydrolase |
Swissprots | Q5W199 A1Z1Q3 B0QZ39 A6NFF7 Q495E0 Q6ZN71 Q0P6D5 B3KWV0 |
Accessions | A1Z1Q3 EAX10302 AK125899 BAG54262 AK131348 BAD18504 BC018687 AAH18687 BC035876 BC036403 BC101216 BC101217 BC101218 BC101219 BC126936 BC128036 BX281637 DB125529 DB495787 DR001087 EF159161 ABM46908 XM_011529168 XP_011527470 XM_011529169 XP_011527471 NM_001033087 NP_001028259 NM_080676 NP_542407 |
Function | Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}. |
Subcellular Location | Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. |
MACROD2 CRISPR/Cas9 KO Plasmid (h) - sc-414497 from Santa Cruz Biotechnology
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MACROD2 HDR Plasmid (h) - sc-414497-HDR from Santa Cruz Biotechnology
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MACROD2 Double Nickase Plasmid (h) - sc-414497-NIC from Santa Cruz Biotechnology
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MACROD2 Double Nickase Plasmid (h2) - sc-414497-NIC-2 from Santa Cruz Biotechnology
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MACROD2 CRISPR Activation Plasmid (h) - sc-414497-ACT from Santa Cruz Biotechnology
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MACROD2 CRISPR Activation Plasmid (h2) - sc-414497-ACT-2 from Santa Cruz Biotechnology
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MACROD2 Lentiviral Activation Particles (h) - sc-414497-LAC from Santa Cruz Biotechnology
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MACROD2 Lentiviral Activation Particles (h2) - sc-414497-LAC-2 from Santa Cruz Biotechnology
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MACROD2 siRNA (h) - sc-72705 from Santa Cruz Biotechnology
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MACROD2 shRNA Plasmid (h) - sc-72705-SH from Santa Cruz Biotechnology
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MACROD2 shRNA (h) Lentiviral Particles - sc-72705-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU006991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12891 from Sigma-Aldrich
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MACROD2 siRNA (Human) - CRJ5314 from Cohesion Biosciences
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shRNA set against Human Macrod2 (NM_080676.5) - SHH336475 from Creative biogene
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MACROD2 shRNA Plasmid (Human) - CHJ5314 from Cohesion Biosciences
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MACROD2 miRNA 3'UTR clone - MiUTR1H-01306 from Creative biogene
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MACROD2 miRNA 3'UTR clone - MiUTR1H-01307 from Creative biogene
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