| Gene Symbol |
ANKRD13B
|
| Entrez Gene |
124930
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ankyrin repeat domain 13B
|
| Other Description |
ankyrin repeat domain-containing protein 13B
|
| Swissprots |
Q86YJ7 Q8N7S9
|
| Accessions |
EAW51199 EAW51200 EAW51201 EAW51202 EAW51203 Q86YJ7 AK000425 AK092673 BAG52589 AK097716 BAC05148 AK098421 BAC05304 BC032554 AAH32554 BC062597 AAH62597 BG029526 DA445860 XM_005257920 XP_005257977 XM_011524319 XP_011522621 XM_011524320 XP_011522622 XM_011524321 XP_011522623 XR_934365 XR_934366 NM_152345 NP_689558
|
| Function |
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22298428}. Late endosome {ECO:0000269|PubMed:22298428}. Early endosome {ECO:0000269|PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
|