| Gene Symbol |
IL1B
|
| Entrez Gene |
768274
|
| Alt Symbol |
-
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1, beta
|
| Other Description |
IL-1 beta|interleukin-1 beta|interleukin-beta
|
| Swissprots |
P41687
|
| Accessions |
P41687 M92060 AAA30814 NM_001077414 NP_001070882
|
| Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
|
| Subcellular Location |
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Apoptosis, NOD-like receptor signaling pathway, Prion diseases, MAPK signaling pathway
|
