| Gene Symbol | Msh2 |
|---|---|
| Entrez Gene | 17685 |
| Alt Symbol | AI788990 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mutS homolog 2 (E. coli) |
| Other Description | DNA mismatch repair protein Msh2|mutS protein homolog 2 |
| Swissprots | P43247 |
| Accessions | EDL38635 P43247 AK051960 AK078775 AK157842 BAE34223 AK166179 AK206893 AK216255 AK217675 BC047117 AAH47117 BC050897 AAH50897 U21011 AAA75027 X81143 CAA57049 NM_008628 NP_032654 |
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformationa |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Top Pathways | Mismatch repair, Colorectal cancer |
DNA mismatch repair protein Msh2, Msh2, Mouse, ELISA Kit - E8706m from ARP American Research Products
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mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) , ELISA Kit - MBS9317113 from MyBioSource
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Mouse Msh2 ELISA Kit - E051115 from Biobool
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MSH2 ELISA Kit (Mouse) (OKEH05032) - OKEH05032 from Aviva Systems Biology
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DNA mismatch repair protein Msh2, ELISA Kit - MBS2880640 from MyBioSource
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