| Gene Symbol |
CYP2C19
|
| Entrez Gene |
1557
|
| Alt Symbol |
CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily C, polypeptide 19
|
| Other Description |
(R)-limonene 6-monooxygenase|(S)-limonene 6-monooxygenase|(S)-limonene 7-monooxygenase|S-mephenytoin 4-hydroxylase|cytochrome P-450 II C|cytochrome P450 2C19|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19|cytochrome P450-11A|cytochrome P450-254C|flavoprotein-linked monooxygenase|mephenytoin 4'-hydroxylase|mephenytoin 4-hydroxylase|microsomal monooxygenase|xenobiotic monooxygenase
|
| Swissprots |
Q8WZB1 Q9UCD4 P33259 Q8WZB2 P33261
|
| Accessions |
AAL31347 AAL31348 AAV41877 ABZ69068 ABZ69069 ABZ69070 ABZ69071 ABZ69072 ABZ69073 ABZ69074 ABZ69075 ABZ69076 ABZ69077 ABZ69078 ABZ69079 ABZ69080 ABZ69081 ABZ69082 ABZ69083 ABZ69084 ABZ69085 ABZ69086 ABZ69087 ABZ69088 ABZ69089 ABZ69090 ABZ69091 ABZ69092 ABZ69093 ABZ69094 ABZ69095 ABZ69096 ABZ69097 ABZ69098 ABZ69099 ABZ69100 ABZ69101 ABZ69102 ABZ69103 ABZ69104 ABZ69105 ABZ69106 ABZ69107 ABZ69108 ABZ69109 ABZ69110 ABZ69111 ABZ69112 ABZ69113 ABZ69114 ABZ69115 ABZ69116 ABZ69117 ABZ69118 ABZ69119 ABZ69120 ABZ69121 ABZ69122 ABZ69123 ABZ69124 ABZ69125 BAD02827 P33261 BC111846 AAI11847 CB158473 CB161988 M61854 AAB59426 X65962 CAA46778 NM_000769 NP_000760
|
| Function |
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Top Pathways |
Chemical carcinogenesis, Arachidonic acid metabolism, Linoleic acid metabolism, Drug metabolism - cytochrome P450
|