| Gene Symbol |
CARD18
|
| Entrez Gene |
59082
|
| Alt Symbol |
ICEBERG, UNQ5804, pseudo-ICE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase recruitment domain family, member 18
|
| Other Description |
ICEBERG caspase-1 inhibitor|caspase recruitment domain-containing protein 18|caspase-1 inhibitor Iceberg
|
| Swissprots |
P57730 A2RRF8
|
| Accessions |
EAW67065 P57730 AF208005 AAG23528 AI189838 AW295205 AY358231 AAQ88598 BC131610 AAI31611 NM_021571 NP_067546
|
| Function |
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. {ECO:0000269|PubMed:11051551}.
|
| Tissue Specificity |
Primarily expressed in the heart and placenta. {ECO:0000269|PubMed:11051551}.
|
| Top Pathways |
NOD-like receptor signaling pathway
|