Gene Symbol | CARD18 |
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Entrez Gene | 59082 |
Alt Symbol | ICEBERG, UNQ5804, pseudo-ICE |
Species | Human |
Gene Type | protein-coding |
Description | caspase recruitment domain family, member 18 |
Other Description | ICEBERG caspase-1 inhibitor|caspase recruitment domain-containing protein 18|caspase-1 inhibitor Iceberg |
Swissprots | P57730 A2RRF8 |
Accessions | EAW67065 P57730 AF208005 AAG23528 AI189838 AW295205 AY358231 AAQ88598 BC131610 AAI31611 NM_021571 NP_067546 |
Function | Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B. {ECO:0000269|PubMed:11051551}. |
Tissue Specificity | Primarily expressed in the heart and placenta. {ECO:0000269|PubMed:11051551}. |
Top Pathways | NOD-like receptor signaling pathway |
ICEBERG CRISPR/Cas9 KO Plasmid (h) - sc-417757 from Santa Cruz Biotechnology
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ICEBERG HDR Plasmid (h) - sc-417757-HDR from Santa Cruz Biotechnology
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ICEBERG Double Nickase Plasmid (h) - sc-417757-NIC from Santa Cruz Biotechnology
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ICEBERG Double Nickase Plasmid (h2) - sc-417757-NIC-2 from Santa Cruz Biotechnology
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ICEBERG CRISPR Activation Plasmid (h) - sc-417757-ACT from Santa Cruz Biotechnology
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ICEBERG CRISPR Activation Plasmid (h2) - sc-417757-ACT-2 from Santa Cruz Biotechnology
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ICEBERG Lentiviral Activation Particles (h) - sc-417757-LAC from Santa Cruz Biotechnology
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ICEBERG Lentiviral Activation Particles (h2) - sc-417757-LAC-2 from Santa Cruz Biotechnology
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ICEBERG siRNA (h) - sc-105550 from Santa Cruz Biotechnology
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ICEBERG shRNA Plasmid (h) - sc-105550-SH from Santa Cruz Biotechnology
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ICEBERG shRNA (h) Lentiviral Particles - sc-105550-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5366 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5366 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01320 from Sigma-Aldrich
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CARD18 siRNA (Human) - CRJ1757 from Cohesion Biosciences
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CARD18 - MBS8224108 from MyBioSource
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shRNA set against Human CARD18 (NM_021571.3) - SHH254709 from Creative biogene
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Human CARD18 siRNA - orb272258 from Biorbyt
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CARD18 shRNA Plasmid (Human) - CHJ1757 from Cohesion Biosciences
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CARD18 miRNA 3'UTR clone - MiUTR4H-TG01618 from Creative biogene
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