| Gene Symbol | PDX1 |
|---|---|
| Entrez Gene | 3651 |
| Alt Symbol | GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pancreatic and duodenal homeobox 1 |
| Other Description | IPF-1|IUF-1|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|islet/duodenum homeobox-1|pancreas/duodenum homeobox protein 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1|somatostatin-transactivating factor 1 |
| Swissprots | Q5VYW2 O60594 P52945 |
| Accessions | AAB47101 AAB88463 EAX08420 P52945 AF049893 AAC05157 BC111592 AAI11593 CA771381 CA848737 U30329 AAA74012 U35632 AAA88820 X99894 CAA68169 XR_941578 XR_941579 XR_941580 NM_000209 NP_000200 |
| Function | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| Subcellular Location | Nucleus. Cytoplasm, cytosol {ECO:0000250}. |
| Tissue Specificity | Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). |
| Top Pathways | Type II diabetes mellitus, Maturity onset diabetes of the young |
PDX-1 CRISPR/Cas9 KO Plasmid (h) - sc-400792 from Santa Cruz Biotechnology
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PDX-1 HDR Plasmid (h) - sc-400792-HDR from Santa Cruz Biotechnology
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PDX-1 Double Nickase Plasmid (h) - sc-400792-NIC from Santa Cruz Biotechnology
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PDX-1 Double Nickase Plasmid (h2) - sc-400792-NIC-2 from Santa Cruz Biotechnology
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PDX-1 CRISPR Activation Plasmid (h) - sc-400792-ACT from Santa Cruz Biotechnology
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PDX-1 CRISPR Activation Plasmid (h2) - sc-400792-ACT-2 from Santa Cruz Biotechnology
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PDX-1 Lentiviral Activation Particles (h) - sc-400792-LAC from Santa Cruz Biotechnology
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PDX-1 Lentiviral Activation Particles (h2) - sc-400792-LAC-2 from Santa Cruz Biotechnology
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PDX-1 siRNA (h) - sc-38760 from Santa Cruz Biotechnology
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PDX-1 shRNA Plasmid (h) - sc-38760-SH from Santa Cruz Biotechnology
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PDX-1 shRNA (h) Lentiviral Particles - sc-38760-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16584 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1174 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16584 from Sigma-Aldrich
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PDX1 siRNA (Human) - CRH2446 from Cohesion Biosciences
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PDX-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400792-KO-2 from Santa Cruz Biotechnology
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PDX-1 HDR Plasmid (h2) - sc-400792-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Pdx1 (NM_000209.3) - SHH373108 from Creative biogene
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PDX1 shRNA Plasmid (Human) - CHH2446 from Cohesion Biosciences
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PDX1 miRNA 3'UTR clone - MiUTR4H-TG06583 from Creative biogene
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