| Gene Symbol |
SMAD9
|
| Entrez Gene |
4093
|
| Alt Symbol |
MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMAD family member 9
|
| Other Description |
MAD homolog 9|Mothers against decapentaplegic, drosophila, homolog of, 9|SMAD, mothers against DPP homolog 9|mothers against decapentaplegic homolog 9
|
| Swissprots |
A2A2Y6 O15198 O14989 Q5TBA1
|
| Accessions |
EAX08570 EAX08571 EAX08572 EAX08573 O15198 AK311686 AK314920 AW191604 BC011559 AAH11559 BC067766 BC104760 AAI04761 BC104762 AAI04763 BC143240 AAI43241 BC143256 CN291481 D83760 BAA21128 D83761 BAA21129 DB501041 EU446860 ABZ92389 EU831977 ACE87418 EU832070 ACE86732 XM_005266401 XP_005266458 XM_005266403 XP_005266460 XM_005266404 XP_005266461 XM_006719827 XP_006719890 XM_011535096 XP_011533398 NM_001127217 NP_001120689 NM_005905 NP_005896
|
| Function |
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
|
| Top Pathways |
TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
![Western Blot: SMAD9 Overexpression Lysate (Adult Normal) [NBP2-07690] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMAD9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26224_SMAD9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07690-img0001.jpg)