| Gene Symbol |
BIRC5
|
| Entrez Gene |
493835
|
| Alt Symbol |
-
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
baculoviral IAP repeat containing 5
|
| Other Description |
apoptosis inhibitor survivin|baculoviral IAP repeat-containing 5|baculoviral IAP repeat-containing protein 5|survivin
|
| Swissprots |
Q6I6F4
|
| Accessions |
Q6I6F4 AB182320 BAD23994 NM_001009280 NP_001009280
|
| Function |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome. Chromosome, centromere {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Midbody {ECO:0000250}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (By similarity). {ECO:0000250}.
|
| Top Pathways |
Colorectal cancer, Hippo signaling pathway
|