Gene Symbol | LTB |
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Entrez Gene | 4050 |
Alt Symbol | TNFC, TNFSF3, p33 |
Species | Human |
Gene Type | protein-coding |
Description | lymphotoxin beta (TNF superfamily, member 3) |
Other Description | LT-beta|TNF-C|lymphotoxin-beta|tumor necrosis factor C|tumor necrosis factor ligand superfamily member 3 |
Swissprots | Q52LU8 P78370 Q06643 Q99761 |
Accessions | AAA99888 AAD18089 AAL49954 AAL49955 AAO21134 BAB63395 BAC54938 BAE78640 BAF31273 CAA75069 CAI95950 EAX03425 EAX03426 Q06643 AK312210 BAG35143 BC055090 BC055094 BC069330 AAH69330 BC093783 AAH93783 L11015 AAA36191 U79029 AAB37342 U89922 AAC51769 NM_002341 NP_002332 NM_009588 NP_033666 |
Function | Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Spleen and thymus. |
Top Pathways | Cytokine-cytokine receptor interaction, Rheumatoid arthritis |
LT-β siRNA (h) - sc-39828 from Santa Cruz Biotechnology
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LT-β shRNA Plasmid (h) - sc-39828-SH from Santa Cruz Biotechnology
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LT-β shRNA (h) Lentiviral Particles - sc-39828-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU221981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12812 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12812 from Sigma-Aldrich
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LTB siRNA (Human) - CRH2739 from Cohesion Biosciences
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shRNA set against Human LTB (NM_002341.1) - SHH335423 from Creative biogene
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shRNA set against Human LTB(NM_002341.1) - SHH165715 from Creative biogene
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shRNA set against Human LTB(NM_009588.1) - SHH165725 from Creative biogene
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shRNA set against Human LTB(NM_002341.1) - SHH165765 from Creative biogene
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LTB shRNA Plasmid (Human) - CHH2739 from Cohesion Biosciences
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LTB miRNA 3'UTR clone - MiUTR1H-05948 from Creative biogene
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LTB miRNA 3'UTR clone - MiUTR1H-05949 from Creative biogene
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