ICK

Gene Symbol ICK
Entrez Gene 22858
Alt Symbol ECO, LCK2, MRK
Species Human
Gene Type protein-coding
Description intestinal cell (MAK-like) kinase
Other Description MAK-related kinase|hICK|laryngeal cancer kinase 2|serine/threonine protein kinase|serine/threonine-protein kinase ICK
Swissprots A7MD41 O75985 Q8IYH8 Q9BX17 Q5THL2 Q9NYX3 Q9UPZ9
Accessions EAX04400 EAX04401 EAX04402 EAX04403 EAX04404 Q9UPZ9 AB023153 BAA76780 AF152469 AAG43364 AF225919 AAF37278 AI699136 AJ420557 AK074892 BAG52026 BC035807 AAH35807 BC136420 AAI36421 BC136421 AAI36422 BC152464 AAI52465 BX647493 DA456873 XM_011514419 XP_011512721 XM_011514420 XP_011512722 XM_011514421 XP_011512723 NM_014920 NP_055735 NM_016513 NP_057597
Function Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12103360}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62726}. Cell projection, cilium {ECO:0000269|PubMed:24797473}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9JKV2}. Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:12103360, ECO:0000269|PubMed:24797473}.
Tissue Specificity Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. {ECO:0000269|PubMed:10699974, ECO:0000269|PubMed:12103360}.

ICK (G-8) - sc-365244 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICK (G-8): sc-365244. Western blot analysis of ICK expression in NIH/3T3 whole cell lysate.

ICK (C-19) - sc-48020 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICK (C-19): sc-48020. Western blot analysis of ICK expression in SW480 whole cell lysate.

ICK (M-40) - sc-134510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-ICK (phospho Y159) antibody - ab138435 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ICK (phospho Y159) antibody (ab138435) at 1/500 dilution + NIH 3T3 cells starved for 24 hours

Anti-ICK antibody - ab196964 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ICK antibody (ab196964) at 1/500 dilutionLane 1 : 293 cell extrtact with synthesized peptideLane 2 : 293 cell extrtactLane 3 : COS7 cell extrtact

Anti-ICK antibody - ab103817 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ICK antibody (ab103817) at 1/500 dilution + Human placenta tissue lysate at 50 µg

Anti-ICK antibody - ab128260 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ICK antibody (ab128260) at 1 µg/ml + 721_B cell lysate at 10 µg

Anti-ICK antibody - N-terminal - ab194411 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-ICK antibody - N-terminal (ab194411) at 1/500 dilution + NIH3T3 cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-ICK Antibody (aa380-430) - LS-C190917 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICK Antibody (phospho-Tyr159) - LS-C291583 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICK Antibody - LS-C310681 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICK Antibody - LS-C47367 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of ICK in HeLa cell lysate. Lane 1 shows pre-immune sera. Lane 2 shows antibody tested at 1:5000 dilution.

Anti-ICK Antibody (aa448-497) IHC-plus™ - LS-B8265 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ICK antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8265 dilution 5-10 ug/ml.

Anti-ICK Antibody (aa241-290) - LS-C119329 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using ICK Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ICK Antibody (phospho-Tyr159) - LS-C199092 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from NIH-3T3 cells treated with starved 24h, using ICK (Phospho-Tyr159) Antibody. The lane on the right was incubated with synthetic peptide.

Anti-ICK Antibody (aa125-174) - LS-C199091 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from NIH-3T3 cells, treated with PBS 10uM 60', using ICK Antibody. The lane on the right was incubated with synthetic peptide.

ICK Antibody - NBP2-23656 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ICK Antibody [NBP2-23656] - Analysis of ICK in HeLa cell lysate. Lane 1 shows pre-immune sera. Lane 2 shows NBP2-23656 tested at 1:5000 dilution.

ICK Antibody - NBP1-81459 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ICK Antibody - NBP1-55755 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ICK Antibody [NBP1-55755] - Analysis of HeLa cells, using ICK Antibody. The picture on the right is treated with the synthesized peptide.

ICK Antibody - H00022858-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: ICK Antibody [H00022858-A01] - ICK polyclonal antibody (A01), Lot # CAO0060412QCS1. Western Blot analysis of ICK expression in NIH/3T3.

ICK Antibody - H00022858-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ICK Antibody [H00022858-D01P] - Analysis of ICK expression in human placenta.

ICK(Tyr159) Polyclonal Antibody - bs-15535R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ICK Polyclonal Antibody - bs-15536R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ICK antibody produced in rabbit - SAB1401574 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-ICK, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401574</B>: Antibody concentration: 1.0 - 5.0 μg/mL. Specific band of ~71.43 kDa using human placenta lysate.

Anti-ICK antibody produced in rabbit - SAB4500902 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ICK: <B>Cat. No. SAB4500902</B>: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-ICK antibody. Cells on the left were treated with the Anti-ICK antibody. Cells on the right (negative control) were treated with both Anti-ICK antibody and the synthesized immunogen peptide.
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