| Gene Symbol |
ICK
|
| Entrez Gene |
22858
|
| Alt Symbol |
ECO, LCK2, MRK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
intestinal cell (MAK-like) kinase
|
| Other Description |
MAK-related kinase|hICK|laryngeal cancer kinase 2|serine/threonine protein kinase|serine/threonine-protein kinase ICK
|
| Swissprots |
A7MD41 O75985 Q8IYH8 Q9BX17 Q5THL2 Q9NYX3 Q9UPZ9
|
| Accessions |
EAX04400 EAX04401 EAX04402 EAX04403 EAX04404 Q9UPZ9 AB023153 BAA76780 AF152469 AAG43364 AF225919 AAF37278 AI699136 AJ420557 AK074892 BAG52026 BC035807 AAH35807 BC136420 AAI36421 BC136421 AAI36422 BC152464 AAI52465 BX647493 DA456873 XM_011514419 XP_011512721 XM_011514420 XP_011512722 XM_011514421 XP_011512723 NM_014920 NP_055735 NM_016513 NP_057597
|
| Function |
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12103360}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q62726}. Cell projection, cilium {ECO:0000269|PubMed:24797473}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9JKV2}. Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:12103360, ECO:0000269|PubMed:24797473}.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. {ECO:0000269|PubMed:10699974, ECO:0000269|PubMed:12103360}.
|