Gene Symbol | ATP12A |
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Entrez Gene | 479 |
Alt Symbol | ATP1AL1 |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+/K+ transporting, nongastric, alpha polypeptide |
Other Description | ATPase, Na+/K+ transporting, alpha polypeptide-like 1|non-gastric H(+)/K(+) ATPase alpha subunit|non-gastric H(+)/K(+) ATPase subunit alpha|potassium-transporting ATPase alpha chain 2|proton pump |
Swissprots | P54707 Q13816 Q8N5U2 Q5W035 Q16734 Q13817 |
Accessions | AAA35576 AAC37589 CAA49477 CAA49478 EAX08343 EAX08344 EAX08345 EAX08346 P54707 AK292968 BAF85657 AK303498 BAG64531 BC031609 AAH31609 CA450333 DB216724 DB232979 JF432299 ADZ15516 M16797 AAA51802 U02076 AAB37755 NM_001185085 NP_001172014 NM_001676 NP_001667 |
Function | Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level). {ECO:0000269|PubMed:22179016, ECO:0000269|PubMed:9872395}. |
Top Pathways | Oxidative phosphorylation |
ATP1AL1 CRISPR/Cas9 KO Plasmid (h) - sc-407397 from Santa Cruz Biotechnology
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ATP1AL1 HDR Plasmid (h) - sc-407397-HDR from Santa Cruz Biotechnology
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ATP1AL1 Double Nickase Plasmid (h) - sc-407397-NIC from Santa Cruz Biotechnology
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ATP1AL1 Double Nickase Plasmid (h2) - sc-407397-NIC-2 from Santa Cruz Biotechnology
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ATP1AL1 CRISPR Activation Plasmid (h) - sc-407397-ACT from Santa Cruz Biotechnology
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ATP1AL1 CRISPR Activation Plasmid (h2) - sc-407397-ACT-2 from Santa Cruz Biotechnology
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ATP1AL1 Lentiviral Activation Particles (h) - sc-407397-LAC from Santa Cruz Biotechnology
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ATP1AL1 Lentiviral Activation Particles (h2) - sc-407397-LAC-2 from Santa Cruz Biotechnology
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ATP1AL1 siRNA (h) - sc-105105 from Santa Cruz Biotechnology
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ATP1AL1 shRNA Plasmid (h) - sc-105105-SH from Santa Cruz Biotechnology
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ATP1AL1 shRNA (h) Lentiviral Particles - sc-105105-V from Santa Cruz Biotechnology
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ATP12A RNAi - H00000479-R02 from Novus Biologicals
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MISSION® esiRNA - EHU043951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3675 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3675 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02577 from Sigma-Aldrich
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ATP12A siRNA (Human) - CRH0335 from Cohesion Biosciences
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ATP12A - MBS8212254 from MyBioSource
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shRNA set against Human ATP12A (NM_001676.5) - SHH242434 from Creative biogene
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Human ATP12A siRNA - orb260837 from Biorbyt
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ATP12A shRNA Plasmid (Human) - CHH0335 from Cohesion Biosciences
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ATP12A miRNA 3'UTR clone - MiUTR4H-TG10653 from Creative biogene
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