CDK5

Gene Symbol	CDK5
Entrez Gene	1020
Alt Symbol	PSSALRE
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 5
Other Description	TPKII catalytic subunit|cell division protein kinase 5|cyclin-dependent-like kinase 5|protein kinase CDK5 splicing|serine/threonine-protein kinase PSSALRE|tau protein kinase II catalytic subunit
Swissprots	A1XKG3 Q00535
Accessions	EAL24498 EAW54049 EAW54050 EAW54051 Q00535 AK026533 AY049778 AAL15435 AY927560 BC005115 AAH05115 BP309068 BT006680 AAP35326 BU527089 CA429180 CB114175 CR457041 CAG33322 DB487008 DQ411039 ABD66016 L04658 X66364 CAA47007 NM_001164410 NP_001157882 NM_004935 NP_004926
Function	Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many
Subcellular Location	Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5.
Tissue Specificity	Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary. {ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:19693690}.
Top Pathways	Axon guidance, Alzheimer's disease, Cocaine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CDK5-Over-expression-Lysate - LY10943a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CDK5 293T Cell Transient Overexpression Lysate(Denatured) - H00001020-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CDK5 293T Cell Transient Overexpression Lysate(Denatured) - H00001020-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CDK5 overexpression lysate - LY431225 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CDK5 293 Cell Lysate - 401392 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Cdk5 Overexpression Lysate (Denatured) - H00001020-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Cdk5 Overexpression Lysate (Denatured) - H00001020-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Cdk5 Overexpression Lysate (Native) - NBL1-09040 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CDK5 Over-expression Lysate Product - GWB-7469AB from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human CDK5 Knockdown Stable Cell Line - CSC-DC002875 from Creative biogene Category Cell Line Species Human

CDK5 KO Cell Lysate-HEK293T - CLKO-0724 from Creative biogene Category Cell Lysate

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